Results 201 to 210 of about 255,405 (374)

Non‐Targeting shRNA‐Encoded Plasmid DNA Enhances Protective Immunity Through RIDD‐RIG‐I Signaling Pathway in the Zika Virus Animal Model

Advanced Science, EarlyView.
We present a novel DNA vaccine platform featuring intrinsic, non‐targeting dsRNA that significantly enhances immune responses by activating the regulated IRE1‐dependent decay‐RIG‐I signaling pathway. This research elucidates a previously uncharacterized mechanism for dsRNA‐mediated innate immune activation.
Min‐Syuan Huang, Hung‐Chun Liao, Po Peng, Wan‐Ling Wu, Kit Man Chai, Mei‐Yu Chen, Guann‐Yi Yu, Tsung‐Hsien Chuang, Hsin‐Wei Chen, Chuang‐Rung Chang, Shih‐Jen Liu   +10 more
wiley   +1 more source

Tool-based euthanasia methods for broiler chicks: Evaluating welfare outcomes of Iris and Kelly scissors. [PDF]

Poult Sci
Gore A, Alves LKS, Silva GV, Carnaccini S, Nelson NC, Reichelt S, Pairis-Garcia MD, Crespo R, Pullin AN.   +8 more
europepmc   +1 more source

Voluntary euthanasia [PDF]

Palliative Medicine, 1992
openaire   +1 more source

EIF5A Couples Translational Control With Transcriptional Reprogramming Through Chromocenter Reorganization During Spermiogenesis

Advanced Science, EarlyView.
The translation factor Eukaryotic translation initiation factor 5A (eIF5A) is essential for male fertility in mice. It supports the translation of proteins crucial for heterochromatin organization and acrosome formation. eIF5A deficiency disrupts chromocenter integrity, increases chromatin accessibility, and causes transcriptional dysregulation ...
Yuling Cai, Tongtong Li, Qian Fang, Ziyou Bao, Feng Kong, Huitao Qi, Hanzhen Li, Mingyu Zhang, Wei Wang, Yongxia Guan, Wenbo Liu, Xiangfeng Chen, Zi‐Jiang Chen, Xiaohua Jiang, Xin Wang, Hongbin Liu   +15 more
wiley   +1 more source

Patient autonomy versus family centric decision making in end-of-life care. [PDF]

Pak J Med Sci
Shahid R, Irfan M, Shah SSH.
europepmc   +1 more source

Gabpα‐Pparγ Complex Determines Glycolytic Capacity and Lactic Acid Homeostasis in Brown Fat

Advanced Science, EarlyView.
This study identifies the Gabpα–Pparγ complex as a key transcriptional regulator that couples glycolysis to lactate‐driven thermogenesis in brown adipose tissue by directly activating Eno1 transcription. ‌Competitive disruption of this interaction impairs lactate metabolism and thermogenic capacity.
Zhihan Wang, Huanyu Wang, Qianqian Kang, Ruping Pan, Rui He, Min Yang, Jiadai Liu, Xuemin Peng, Yuyu Xie, Hongyan Deng, Wenshe Wang, Zengzhe Zhu, Jing Ge, Yulian Liu, Ronghui Gao, Yaming Guo, Peng Yu, Limeng Pan, Danpei Li, Pema Maretich, Xiaoping Luo, Xuefeng Yu, Yong Chen   +22 more
wiley   +1 more source

Conceptual barriers to palliative sedation: insights from focus group interviews with specialist palliative care professionals. [PDF]

BMC Palliat Care
Torvund S, Thoresen L, Magelssen M, Fredheim OM.   +3 more
europepmc   +1 more source

Euthanasia of dogs as control of Visceral Leishmaniasis: brazilian law from a technical and ethical-moral view

Ana Beatriz Pinto Costa Name, Caio Ferreira Repik, Rodrigo Buzinaro Suzuki, Cláudia Sampaio Fonseca Repetti, Fábio Fernando Ribeiro Manhoso, Isabela Bazzo da Costa, Patrícia dos Santos Cincotto Bueno, Camila Dias Porto, Camila Dias Porto   +8 more
openalex   +2 more sources

AXL Promotes Ischemic Myelin Repair Through Alleviating Myelin Debris Deposition and Lipid Droplets Accumulation

Advanced Science, EarlyView.
Microglial AXL drives white matter repair after stroke by orchestrating the cleanup of myelin debris. Mechanistically, AXL signals through EGR1 to boost Smpd1 transcription, regulating sphingolipid metabolism and preventing lipid droplet toxicity. Restoring the pathway with ASM therapy mitigates damage, positioning AXL as a key node for therapeutic ...
Junqiu Jia, Yonghui Gan, Jia Li, Lilin Li, Hailan Meng, Min Sun, Lei Ye, Rui Mao, Xiang Cao, Shengnan Xia, Xinyu Bao, Renyuan Liu, Meijuan Zhang, Yun Xu   +13 more
wiley   +1 more source

Clinical Reasoning About Timely Euthanasia of Compromised Pigs. [PDF]

Vet Sci
Kschonek J, Winkelmann T, Kreienbrock L, Grosse Beilage E.   +3 more
europepmc   +1 more source