Results 91 to 100 of about 423,821 (335)

Time-Energy Tradeoffs for Evacuation by Two Robots in the Wireless Model

open access: yes, 2019
Two robots stand at the origin of the infinite line and are tasked with searching collaboratively for an exit at an unknown location on the line. They can travel at maximum speed $b$ and can change speed or direction at any time.
A Beck   +17 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

The British Adriatic Squadron and the evacuation of Serbs from the Albanian coast 1915-1916 [PDF]

open access: yesBalcanica, 2018
Unpublished sources and archival material can still shed fresh light upon the history of the evacuation of the Serbian Army and civilian refugees from the Albanian coast in 1915-1916.
Ković Miloš
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

DESIGN OF AUTOMATED CONTROL SYSTEM EVACUATION IN AN EMERGENCY ON THE PRINCIPLE OF SYSTEMS ENGINEERING

open access: yesНаучный вестник МГТУ ГА, 2016
One of the objectives of the management of infrastructure facilities is to ensure efficient evacuation in an emergency. The problem of the evacuation is related to the heterogeneity of data, its’ large volume, the loss of part of the information ...
S. S. Valeev   +2 more
doaj  

Guidelines for assessing pedestrian evacuation software applications [PDF]

open access: yes, 2007
This paper serves to clearly identify and explain criteria to consider when evaluating the suitability of a pedestrian evacuation software application to assess the evacuation process of a building.
Castle, C.J.E.
core  

Group dynamic behavior and psychometric profiles as substantial driver for pedestrian dynamics

open access: yes, 2012
Our current research lays emphasis on the extended pedestrian perception and copes with both the dynamic group behavior and the individual evaluation of situations, and hence, rather focuses on the tactical level of movement behavior.
Fricke, Hartmut   +3 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Distributed agent-based building evacuation simulator [PDF]

open access: yes, 2012
The optimisation of the evacuation of a building plays a fundamental role in emergency situations. The behaviour of individuals, the directions that civilians receive, and the actions of the emergency personnel, will affect the success of the operation ...
Filippoupolitis, Avgoustinos   +6 more
core  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

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