Results 81 to 90 of about 145,096 (291)

Military Routine in Rear City in 1941–1945 (Case of Alma-Ata)

open access: yesВестник Волгоградского государственного университета. Серия 4. История, регионоведение, международные отношения, 2020
Introduction. The purpose of this article is to highlight the features of daily life in cities of rearguard during World War II (as exemplified by Alma-Ata), the strategy of survival of people in the extremely difficult war years (1941–1945).
Roza S. Zharkynbayeva   +2 more
doaj   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

open access: yesFEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey   +4 more
wiley   +1 more source

Development of a Mass Evacuation Decision Support Tool

open access: yes, 2021
This study presents a sequential modelling framework of a mass evacuation decision support (MEDS) tool and develops countermeasures to improve mass evacuation processes. The study develops a large-scale traffic evacuation microsimulation model to design,
Alam, MD Jahedul
core  

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

open access: yesFEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez   +4 more
wiley   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

open access: yesFEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen   +8 more
wiley   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

open access: yesFEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav   +4 more
wiley   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

open access: yesFEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata   +3 more
wiley   +1 more source

NUMERICAL SIMULATIONS OF AN EVACUATION FROM A TSUNAMI AT PARANGTRITIS BEACH IN INDONESIA [PDF]

open access: yesScience of Tsunami Hazards, 2015
The tsunami disaster in Calang (Aceh, Indonesia) in December 2004 caused traffic jam at a bottleneck on an evacuation road that was fatal, killing most of the evacuees.
Radianta Triatmadja
doaj  

Identification and characterization of a gene conferring stress resistance in Escherichia coli and cyanobacteria

open access: yesFEBS Open Bio, EarlyView.
Functional screening identified PcSyn14890, a cyanobacteria‐specific protein that enhances growth and stress resistance in E. coli and Synechocystis PCC6803. Although we expected it to function as a molecular chaperone, it was unable to protect against thermal aggregation of GAPDH.
Akiyo Yamada   +7 more
wiley   +1 more source

Application of GIS for a Climate Change Prepared Disaster Management in Csongrád County, Hungary

open access: yesJournal of Environmental Geography, 2018
The work of disaster management can only properly be supported by data stored in certified databases, since correct decisions can be made on the base of such data.
Kitka Gergely   +3 more
doaj   +1 more source

Home - About - Disclaimer - Privacy