Results 61 to 70 of about 423,821 (335)
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Evaluating Traffic Operation Conditions during Wildfire Evacuation Using Connected Vehicles Data
Fire, 2023 With climate change and the resulting rise in temperatures, wildfire risk is increasing all over the world, particularly in the Western United States. Communities in wildland–urban interface (WUI) areas are at the greatest risk of fire.
Salman Ahmad +4 more
doaj +1 more source
, 2002 We present simulations of evacuation processes using a recently introduced cellular automaton model for pedestrian dynamics. This model applies a bionics approach to describe the interaction between the pedestrians using ideas from chemotaxis.
Andreas Schadschneider +17 more
core +1 more source
A BIM-Based Smart System for Fire Evacuation
Future Internet, 2021 Building fires constitute a significant threat that affects property, the environment, and human health. The management of this risk requires an efficient fire evacuation system for buildings’ occupants.
Rania Wehbe, I. Shahrour
semanticscholar +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
A Meso-Scale Petri Net Model to Simulate a Massive Evacuation along the Highway System
Future Transportation, 2023 Natural disasters may require that the residents of the affected area be evacuated immediately using a potentially damaged infrastructure. In this paper, we developed a mesoscopic simulation modeling approach for modeling traffic flow over a large ...
Hamzeh Qabaja +3 more
doaj +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Application of Buoyancy Support System to Secure Residual Buoyancy of Damaged Ships
Journal of Marine Science and Engineering, 2023 SOLAS (Safety of Life at Sea), which was first enacted in 1914 as a result of the Titanic disaster, presents mandatory requirements for ship safety, such as the adoption of watertight bulkheads.
Gyeong Joong Lee +3 more
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Fire, 2021 In Australia, residents can choose to remain to defend their property against bushfire but, since the 2009 Black Saturday bushfires, considerable emphasis is placed on leaving early, well in advance of a bushfire.
Kenneth William Strahan, John Gilbert
doaj +1 more source