Results 51 to 60 of about 294,494 (258)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Evacuation of Persons from Selected Departments in High-Rise Buildings of Healthcare Facilities

Communications, 2016
The article deals with the evacuation of persons from hospital bed wards in high-rise buildings of medical facilities. It presents a proposal for a systems approach and provides a subsequent supportive methodology and tools for planning and ...
Silvie Benesova, Isabela Bradacova, Thomas Jager   +2 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

An extended car following approach using agent based model on evacuation system of micro traffic [PDF]

, 2009
We proposed an extended car-following approach on evacuation system of micro traffic. It is based on the agent model. Parameter which is owned by the agent is the velocity.
Harsono, Tri
core  

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Simulation of evacuation situations in order to protect human lives and material property [PDF]

NBP: Nauka, bezbednost, policija, 2016
The term 'evacuation' presents rather a wide concept, but generally it presents the safest, fastest and shortest way of getting out from endangered objects, situations or places for people, animals and material property to a secure place. The reasons for
Jevtić Radoje
doaj  

Evacuation port seal Patent [PDF]

, 1968
Sealing evacuation port and evacuating vacuum container such as space ...
Woller, J. A.
core   +1 more source

Pedestrian, Crowd, and Evacuation Dynamics

, 2013
This contribution describes efforts to model the behavior of individual pedestrians and their interactions in crowds, which generate certain kinds of self-organized patterns of motion. Moreover, this article focusses on the dynamics of crowds in panic or
A Borgers, A Johansson, A Johansson, A Mintz, A Seyfried, BD Hankin, BD Jacobs, C Burstedde, CW Reynolds, D Elliott, D Garbrecht, D Helbing, D Helbing, D Helbing, D Helbing, D Helbing, D Helbing, D Helbing, D Helbing, D Helbing, D Helbing, D Helbing, D Helbing, D Helbing, D Helbing, D Helbing, D Helbing, D Helbing, D Helbing, E Quarantelli, F Radjai, G LeBon, G Peng, GG Løvås, GH Ristow, GK Still, H Klüpfel, H-H Stølum, HH Kelley, HW Hamacher, I Rodríguez-Iturbe, J Kerridge, J Klockgether, J Pauls, J Surowiecki, J Tubbs, JJ Fruin, JL Bryan, JP Keating, K Ando, K Lewin, KR Sreenivasan, LF Henderson, LP Kadanoff, M Ebihara, M Fukui, M Isobe, M Muramatsu, ME Cates, N Ashford, N Ketchell, NE Miller, NE Miller, NJ Smelser, NR Johnson, NS Glance, P Bak, PA Johnson, PA Thompson, PG Gipps, R Axelrod, R Axelrod, R Brown, RH Turner, RL Hughes, S Ghashghaie, S Hoogendoorn, S Okazaki, SJ Older, SJ Yuhaski Jr, SP Hoogendoorn, T Baeck, T Kretz, T Schelling, Transportation Research Board, VJ Blue, VM Predtechenskii, WH Whyte   +87 more
core   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Out of Control in the Eye of the Storm: Hurricane Evacuation Experiences and Posttraumatic Stress Symptoms in Evacuated and Non-Evacuated Families

Trauma Care
Background/Objectives: Hurricane exposure is a growing public health concern that frequently results in posttraumatic stress symptoms (PTSS) in families. Research suggests that contextual factors, including whether or not individuals evacuate, evacuation
Rachel C. Bock, Jessy L. Thomas, BreAnne A. Danzi   +2 more
doaj   +1 more source