Results 91 to 100 of about 167,990,442 (263)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Evaluation and the Environmental Democracy of European Cities

, 2010
Since its early days, environmental assessment aroused high expectations about its ability to insinuate ecological rationalities into worldviews, institutions, and social practices.
Alessandro Bonifazi
core  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Evaluation of the cost effectiveness of d-cracking preventive measures

, 2001
"September 2001."; Includes bibliographical references (leaf 44-45).; Final report.; Performed by Bowling Green State University College of Technology for Ohio Dept.
Chapin, L. Travis., Bowling Green State University. College of Technology.   +1 more
core  

School principals' proposals for preventive actions to improve mental health

BACKGROUND: School principals face a demanding work situation that puts them at risk for stress-related poor mental health. Ideally, preventive actions should be based on knowledge about the underlying notions that motivate action.
Håkansson, Carita, Arvidsson, Inger,, Kai Österberg, Carita Håkansson, Persson, Roger,, Nilsson, Kerstin, Persson, Roger, Ulf Leo, Nilsson, Kerstin,, Roger Persson, Österberg, Kai,, Håkansson, Carita,, Leo, Ulf, Arvidsson, Inger, Inger Arvidsson, Kerstin Nilsson, Leo, Ulf,, Österberg, Kai   +17 more
core   +2 more sources

Relevance of a preventive model of osteomyoarticular lesions in young adults

Medisan
Introduction: Osteomyoarticular lesions among young people that render services for the defense are related to risk factors. The use of preventive models bases its approach on the identification of risk and development of actions for its prevention ...
Ernesto Sánchez Hernández, Gertrudis de la Torre Vega, Lisbet Estrada Ladoy, Mislay Rodríguez García, Nadina Travieso Ramos   +4 more
doaj  

An Integrated Risk Assessment Framework for Construction Sites Using Pythagorean Fuzzy AHP and Classic/Fuzzy Fine-Kinney Method

IEEE Access
The construction industry demonstrates heightened occupational hazard exposure due to the confluence of multifaceted operational processes, variable workplace dynamics, and statistically significant accident occurrence rates. Effective risk assessment is
Mustafa Demirbilek, Sevim Ozulukale Demirbilek   +1 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Psychological well-being and factors affecting it after the COVID-19 pandemic

Frontiers in Psychology
IntroductionThe COVID-19 pandemic has enormously impacted human activity worldwide, partly due to many governments issuing stay-at-home orders and limiting the types of social interactions citizens can engage in.
Towhid Babazadeh, Saber Ghaffari-fam, Farzaneh Shahnavaz-Yoshanluie, Soheila Ranjbaran   +3 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source