Results 101 to 110 of about 289,429 (265)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Modelling vessel fleet composition for maintenance operations at offshore wind farms [PDF]

open access: yes, 2018
Chartering a vessel fleet to support maintenance operations at offshore wind farms (OWF's) constitutes one of the major costs of maintaining this type of installations.
García-Fernández, Inmaculada   +3 more
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

SURVEY INSTRUMENTS FOR A COST STUDY OF HACCP IN THE SEAFOOD INDUSTRY [PDF]

open access: yes
The Hazard Analysis and Critical Control Points (HACCP) approach to assuring food safety was first mandated in the United States in 1995 for the seafood industry, with full implementation to take place by December, 1997.
Caswell, Julie A., Colatore, Corinna
core   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Marketing communication practices of public organizations to prevent human trafficking [PDF]

open access: yesMarketing i Menedžment Innovacij, 2013
The aim of the article. The aim of the article is to analyze marketing communicative measures against human trafficking which were implemented by public organizations in 15 regions of Ukraine in 2011-2012.
T.M. Borysova
doaj  

Development and implementation of preventive-maintenance practices in Nigerian industries.

open access: yes, 2006
A methodology for the development of PM using the modern approaches of FMEA, root-cause analysis, and fault-tree analysis is presented. Applying PM leads to a cost reduction in maintenance and less overall energy expenditure.
Eti, Mark C.   +2 more
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

On the optimality of packet-oriented scheduling in photonic switches with delay lines [PDF]

open access: yes, 2011
Bruneel, Herwig   +5 more
core   +2 more sources

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