Results 71 to 80 of about 289,429 (265)

Preventive Conservation of Vernacular Adobe Architecture at Seismic Risk: The Case Study of a World Heritage Historical City

Buildings
Heritage is strengthened through proactive actions, known as preventive conservation, that are considered before earthquakes, rather than reactive actions addressed when the emergency situation occurs.
Neda Haji Sadeghi, Hamed Azizi-Bondarabadi, Mariana Correia   +2 more
doaj   +1 more source

Does the operations of the National Health Insurance Scheme (NHIS) in Ghana align with the goals of primary health care? Perspectives of key stakeholders in northern Ghana [PDF]

, 2016
In 2005, the World Health Assembly (WHA) of the World Health Organization (WHO) urged member states to aim at achieving affordable universal coverage and access to key promotive, preventive, curative, rehabilitative and palliative health interventions ...
Akazili, James, Awoonor-Williams, John Koku, Dalinjong, Philip Ayizem, Nartey, Harry, Tindana, Paulina   +4 more
core   +2 more sources

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Paying for Quality: Understanding and Assessing Physician Pay-for-Performance Initiatives [PDF]

, 2007
Reviews the structure, prevalence, measurement issues, perception, and impact of current quality incentive programs, and discusses how much and under what circumstances they will improve quality of care.
Jon B. Christianson, Kim Sutherland, Sheila Leatherman   +2 more
core  

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Controle da raiva no Brasil de 1980 a 1990

Revista de Saúde Pública
Descreve-se a situação epidemiológica da raiva no Brasil no período de 1980-1990, em que o Programa Nacional de Profilaxia da Raiva foi estruturado em todo País.
Maria Cristina Schneider, George A. de Almeida, Lúcia Maria Souza, Nélio B. de Morares, Roberta C. Diaz   +4 more
doaj  

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Redução das internações por condições sensíveis à atenção primária no Brasil entre 1998-2009

Revista de Saúde Pública
OBJETIVO: Descrever a tendência de hospitalizações por condições sensíveis à atenção primária entre 1998 e 2009 no Brasil. MÉTODOS: Estudo ecológico de séries temporais com dados secundários referentes às internações hospitalares por condições sensíveis ...
Antonio Fernando Boing, Rafael Baratto Vicenzi, Flávio Magajewski, Alexandra Crispim Boing, Rodrigo Otávio Moretti-Pires, Karen Glazer Peres, Sheila Rubia Lindner, Marco Aurélio Peres   +7 more
doaj  

Integrated reliability centred maintenance approach in public sector facilities management. [PDF]

, 2014
Reliability Centred Maintenance (RCM) is focused on ensuring an asset continues to provide its designed function in its present operating context. Through a number of stages, RCM allows for thorough and constant monitoring of assets to maintain their ...
Bralee, Steve, Marasini, Ramesh
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source