Results 81 to 90 of about 289,429 (265)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Postural defects in children and teenagers as one of the major issues in psychosomatic development

Pediatria i Medycyna Rodzinna, 2017
Postural defect is a set of postural abnormalities defined as minor single deviations from correct posture, which may be repaired with the use of appropriate exercises, passive or active.
Agata Wawrzyniak, Maciej Tomaszewski, Judyta Mews, Anna Jung, Bolesław Kalicki   +4 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Avaliação das ações de aconselhamento. Análise de uma perspectiva de prevenção centrada na pessoa

Cadernos de Saúde Pública
Este trabalho apresenta a avaliação das ações de aconselhamento que se efetuam nos serviços do Sistema Único de Saúde (SUS) nos seguintes contextos institucionais: Centro de Testagem e Aconselhamento (CTA), Serviço de Assistência Especializada em HIV ...
Sandra Lúcia Filgueiras, Suely Ferreira Deslandes   +1 more
doaj  

The assessment of occupational health service quality in Poland

Medycyna Pracy
Background In the face of increasing problems related to lifestyle related diseases, attention is increasingly drawn to the untapped potential of the occupational health service (OHS) in undertaking preventive actions.
Agnieszka Lipińska-Ojrzanowska, Marta Szkiela, Marta Wiszniewska, Jolanta Walusiak-Skorupa   +3 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

The future outlook on allergen immunotherapy in children: 2018 and beyond. [PDF]

, 2018
Allergen immunotherapy (AIT) is the only currently available immune-modifying and aetiological treatment for patients suffering from IgE-mediated diseases.
Arasi S, Corsello G, Pajno GB, Villani A
core   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Evaluation of the ZIG-ZAIDS game: an entertaining educational tool for HIV/Aids prevention

Cadernos de Saúde Pública
This article presents the evaluation process for the ZIG-ZAIDS game, investigating the material's applicability in formal and informal educational contexts, i.e., how the game has been used by health professionals, parents, and the target population (pre-
Virgínia T. Schall, Simone Monteiro, Sandra M. Rebello, Maysa Torres   +3 more
doaj  

Health and healthy lifestyle in association with satisfaction with life [PDF]

Psihološka Obzorja, 2010
The aim of our study was to examine whether risk factors for chronic non-communicable diseases (tobacco use, heavy alcohol consumption, inadequate physical activity and unhealthy eating habits) are associated with satisfaction with life and if they are ...
Eva Novak
doaj