Results 91 to 100 of about 2,034,300 (283)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Addressing Gaps in Educational Evaluation: A Comprehensive Meta-Analysis

open access: yesMimbar Ilmu
Educational evaluation plays a crucial role in ensuring the effectiveness of the learning process. However, various studies indicate gaps in the implementation of effective evaluation methods, such as the lack of a holistic approach and limited valid ...
Yoga Dwi Arianda   +2 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

EDUCATIVE CHANGING PROVIDED BY EDUCATIONAL EVALUATION POLICIES

open access: yesRevista Ibero-Americana de Estudos em Educação, 2016
The theme of evaluation of educational policies presents a trajectory quite rich, as they reflect the studies carried out by different bodies, in particular, the OECD and UNESCO, as well as the abundant national and international literature on this topic.
Correia Paulino Santos
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Low Health Literacy and Evaluation of Online Health Information: A Systematic Review of the Literature

open access: yesJournal of Medical Internet Research, 2015
BackgroundRecent years have witnessed a dramatic increase in consumer online health information seeking. The quality of online health information, however, remains questionable.
Diviani, Nicola   +3 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Evaluating competency-based medical education: a systematized review of current practices

open access: yesBMC Medical Education
Background Few published articles provide a comprehensive overview of the available evidence on the topic of evaluating competency-based medical education (CBME) curricula.
Nouf Sulaiman Alharbi
doaj   +1 more source

WeatherBench: A Benchmark Data Set for Data‐Driven Weather Forecasting

open access: yesJournal of Advances in Modeling Earth Systems, 2020
Data‐driven approaches, most prominently deep learning, have become powerful tools for prediction in many domains. A natural question to ask is whether data‐driven methods could also be used to predict global weather patterns days in advance.
Stephan Rasp   +5 more
doaj   +1 more source

Issues in Sports Forecasting [PDF]

open access: yes
A great amount of effort is spent in forecasting the outcome of sporting events, but few papers have focused exclusively on the characteristics of sports forecasts. Rather, many papers have been written about the efficiency of sports betting markets.
David Sendor   +2 more
core  

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