Results 101 to 110 of about 121,838,606 (299)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
EDUCATIVE CHANGING PROVIDED BY EDUCATIONAL EVALUATION POLICIES
Revista Ibero-Americana de Estudos em Educação, 2016 The theme of evaluation of educational policies presents a trajectory quite rich, as they reflect the studies carried out by different bodies, in particular, the OECD and UNESCO, as well as the abundant national and international literature on this topic.
Correia Paulino Santos
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Illuminative evaluation as a method applied to Australian Government policy borrowing and implementation in higher education [PDF]
, 2015 Any government deciding to invoke widespread change in its higher education sector through\ud implementation of new policies impacts on every institution and all staff and students, often in both\ud the time taken up and the heightened emotions caused ...
Alderman, Lyn, Lyn Alderman
core +1 more source
Evaluating competency-based medical education: a systematized review of current practices
BMC Medical EducationBackground Few published articles provide a comprehensive overview of the available evidence on the topic of evaluating competency-based medical education (CBME) curricula.
Nouf Sulaiman Alharbi
doaj +1 more source
An Explanation of the Process of Theorization in Islamic Governance [PDF]
مطالعات حکمرانی اسلامیThe main objective of this study is to propose a framework for research and theorization in Islamic governance. This article, through a library-based review of existing research in the field of Islamic humanities and the authors' own innovations with a ...
Ehsan Rahimi, Karim Ebrahimi
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Figures of speech : figurative expressions and the management of topic transition in conversation [PDF]
, 1998 In conversation, speakers occasionally use figurative expressions such as “had a good innings,” “take with a pinch of salt,” or “come to the end of her tether.” This article investigates WHERE in conversation such expressions are used, in terms of their ...
Drew, P. +5 more
core +1 more source
Social Impact, a Theoretical Model
Cosmopolitan Civil Societies: An Interdisciplinary Journal, 2014 This paper constructs a theoretical model of social impact as it applies to civil society organisations. It does so by drawing on the recent literature on the topic as well as recently completed empirical studies.
Jenny Onyx
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source