Results 121 to 130 of about 2,034,300 (283)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Podium, 2013 The integrating evaluation conception in the Study Plan D of the Physical Culture career will be always a pertinent and current topic, according to the new orientations about evaluation which indicate the final test realization in all subjects. This fact
Bienvenido Emilio Viera-Sánchez +2 more
doaj
A Systematic Mapping Study about Technologies for Hedonic Aspects Evaluation in Text-based Chatbots
Journal on Interactive SystemsMany studies present and evaluate daily-use systems ranging from information to conversational systems. Chatbots, either text-based or voice-based, have attracted the attention of researchers.
Pamella A. de L. Mariano +4 more
doaj +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Russian Language Studies, 2011 The article studies the possibility of looking at students' videos as a new format of testing. In this case things like setting up tasks and objectives, choosing the topic, selecting material and outlining general requests (ex., the length of the video ...
V V Novichkova
doaj
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Community-based (and driven) development : A critical review [PDF]
Community-based (and driven) development (CBD/CDD) projects have become an important form of development assistance, with the World Bank's portfolio alone approximating 7 billion dollars.
Mansuri, Ghazala, Rao, Vijayendra
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Concept-based Interactive Query Expansion Support Tool (CIQUEST) [PDF]
, 2003 This report describes a three-year project (2000-03) undertaken in the Information Studies Department at The University of Sheffield and funded by Resource, The Council for Museums, Archives and Libraries. The overall aim of the research was to provide
Beaulieu, M., Joho, H., Sanderson, M.
core
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Priorities in public relations research: An international Delphi study [PDF]
, 2008 A Delphi study on the priorities for public relations research, conducted in 2007 amongst academics, practitioners and senior executives of professional and industry bodies in five continents, has ranked the ten most important topics for research and ...
Watson, Tom
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