Results 141 to 150 of about 2,031,288 (321)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

A Systematic Mapping Study about Technologies for Hedonic Aspects Evaluation in Text-based Chatbots

Journal on Interactive Systems
Many studies present and evaluate daily-use systems ranging from information to conversational systems. Chatbots, either text-based or voice-based, have attracted the attention of researchers.
Pamella A. de L. Mariano, Ana Carolina R. de Souza, Guilherme C. Guerino, Ana Paula Chaves, Natasha M. C. Valentim   +4 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Methodological guide for the integration of the evaluation in the study plan d at “Nancy Uranga Romagoza” Faculty

Podium, 2013
The integrating evaluation conception in the Study Plan D of the Physical Culture career will be always a pertinent and current topic, according to the new orientations about evaluation which indicate the final test realization in all subjects. This fact
Bienvenido Emilio Viera-Sánchez, María de las Nieves Díaz-Hernández, Rosa María Tabares-Arévalo   +2 more
doaj  

Application of Chatbots to Help Patients Self-Manage Diabetes: Systematic Review and Meta-Analysis

Journal of Medical Internet Research
BackgroundThe number of people with diabetes is on the rise globally. Self-management and health education of patients are the keys to control diabetes.
Yibo Wu, Jinzi Zhang, Pu Ge, Tingyu Duan, Junyu Zhou, Yiwei Wu, Yuening Zhang, Siyu Liu, Xinyi Liu, Erya Wan, Xinying Sun   +10 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Video as a new testing format

Russian Language Studies, 2011
The article studies the possibility of looking at students' videos as a new format of testing. In this case things like setting up tasks and objectives, choosing the topic, selecting material and outlining general requests (ex., the length of the video ...
V V Novichkova
doaj  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Mind the Hype: A Critical Evaluation and Prescriptive Agenda for Research on Mindfulness and Meditation

Perspectives on Psychological Science, 2018
N. V. Van Dam, Marieke K. van Vugt, David R. Vago, Laura Schmalzl, C. Saron, Andrew Olendzki, T. Meissner, S. Lazar, C. Kerr, Jolie Gorchov, K. Fox, Brent A. Field, Willoughby B. Britton, J. Brefczynski-Lewis, David E. Meyer   +14 more
semanticscholar   +1 more source