Results 91 to 100 of about 56,879 (225)

Red lines and green lights: Gene therapy for inherited erythroid disorders beyond the haemoglobinopathies

British Journal of Haematology, EarlyView.
Gene therapy is revolutionizing treatment paradigms for haemoglobinopathies, establishing a translational framework for disorders that impact red blood cell development. In their paper, Joshi et al. describe the preclinical and early clinical landscape of gene therapies for non‐haemoglobinopathy erythroid disorders and highlight common thematic ...
Gaurav Joshi, Nandakumar Natarajan, Kathryn E. Dickerson, Richard A. Voit   +3 more
wiley   +1 more source

EarlyMind‐ID: Co‐designing an Early‐Signs Informant‐Based Checklist and Tracking Framework for Dementia in Adults With Intellectual Disabilities

British Journal of Learning Disabilities, EarlyView.
ABSTRACT Background Adults with intellectual disabilities, particularly those with Down's syndrome, are at increased risk of developing dementia, yet early changes are often subtle and first noticed by family members or paid support staff rather than clinicians.
Acton Daniel, Waites Robert, Duncan Caroline, Lane Steven, Jaydeokar Sujeet   +4 more
wiley   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Cannabigerol reverses mechanical allodynia through α2A‐adrenergic modulation of thalamocortical signaling in chemotherapy‐induced neuropathy

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and treatment‐resistant side effect of platinum‐based chemotherapy, characterised by mechanical allodynia. Cannabigerol (CBG), a non‐psychoactive cannabinoid, has shown antinociceptive potential, but its site and mechanism of action remain unclear.
Quinn W. Wade, Nathan Morris, Diana E. Sepulveda, Alonso Cortez‐Resendiz, Christopher Brandl, Jennifer E. Lausch, Mariya Starostina, Nicholas M. Graziane   +7 more
wiley   +1 more source

Navigating Ambiguity: Considerations When Making Decisions on Out‐Of‐Home Placement of Siblings

Child &Family Social Work, EarlyView.
ABSTRACT Policy‐makers and professionals recognize the importance of relationships between children and their family system and between children and their siblings in out‐of‐home placement. However, it is not always possible to keep siblings together; separation may be necessary for the child's normal development and even to protect the child's well ...
Vered Shenar‐Golan, Hadas Doron, Tali‐Noy Hindi   +2 more
wiley   +1 more source

Codesigned toolkit for multidisciplinary clinicians caring for children with severe neurological impairment

Developmental Medicine &Child Neurology, EarlyView.
Abstract Aim To evaluate a multipronged toolkit (Connect, Pause and Reflect Toolkit [CPRT]) codesigned to support clinicians' professional fulfilment, meaning, and multidisciplinary connection when caring for children with severe neurological impairment. Method This study used convergent mixed‐methods design. Participants reviewed CPRT and completed an
Suzanne M. Nevin, Fleur A. Le Marne, Nancy E. Briggs, Erin Beavis, Rebecca Macintosh, Elizabeth E. Palmer, Rachel McLoughlin, CPR Advisory Group, Anna van Beek, Carola Wittekind, Carolyn Shalhoub, Christine Yuen‐Yan Lau, Christopher Elliot, David Rogers, Devika Wijetilaka, Elizabeth Argent, Elizabeth Cotterell, Erica Elizabeth Jacobson, Hugh McCarthy, Hugo Sampaio, Jacqueline Dalby‐Payne, Katrina Doyle, Kaustuv Bhattacharya, Michelle Lorentzos, Rob Slade, Ruth Evans, Sekhar Pillai, Shekeeb Mohammad, Susie Piper, Vanessa Sarkozy, Kylie Stark, Joanne Ging, Rani Sachdev, Kenneth Nunn, Ann Bye   +34 more
wiley   +1 more source

Cardiovascular‐Kidney‐Metabolic Syndrome: Conceptualising an Approach to Health Economic Modelling

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Cardiovascular‐kidney‐metabolic (CKM) syndrome has developed into a global public health crisis. Although integrated care is increasingly used to treat patients with CKM, current health economic models fail to capture the value of considering the CKM syndrome as a unified condition.
Volker Foos, Jieling Chen, Phil McEwan, Marc Evans, Pardeep S. Jhund, Paul R. Kalra, Hongtu Zhu, David C. Wheeler, Geraint Roberts, Martin R. Cowie, Andrew H. Briggs   +10 more
wiley   +1 more source

Clinicopathological findings, correlations and outcomes in patients with renal disease and living with antiretroviral‐treated human immunodeficiency virus infection

Internal Medicine Journal, EarlyView.
Abstract Background and Aims Antiretroviral therapy (ART) has modified the incidence of renal complications and the patterns of renal disease in people living with Human Immunodeficiency Virus (PLWH). We reviewed (2011–2021) the progress and outcomes (follow‐up to mid‐2025) of 158 such individuals.
Jacqueline A. Evans, Christopher S. B. Sia, Gopal Basu, Orla O’Brien, Alan H. Pham, Rowan G. Walker   +5 more
wiley   +1 more source

When to consider an inborn error of immunity: clues for physicians

Internal Medicine Journal, EarlyView.
Abstract The term inborn errors of immunity (IEIs) refers to the rapidly expanding group of genetic disorders causing dysregulation of the immune system. With improved genetic testing in recent years, the number of defined IEIs and their range of phenotypic presentations has grown vastly, with more than 550 IEIs now described.
Meera Thangarajah, Lucinda J. Berglund
wiley   +1 more source

Obstetric and Perinatal Outcomes of Pregnancies with Evans Syndrome: A 12-Year Retrospective Study at a Tertiary Care Center in South India

Current Medical Issues
Background: Evans syndrome (ES), a chronic autoimmune disorder, is infrequently diagnosed during pregnancy and the outcomes are underreported. The aim of the study was to examine the incidence, as well as the maternal and perinatal outcomes of ES in ...
Sirisha Andey, Manisha Madhai Beck, Mintoo Tergestina, Reka Karuppusamy, John Mathew, Manish Kumar   +5 more
doaj   +1 more source