Results 21 to 30 of about 168,314 (195)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

La conducta humana del contribuyente en el cumplimiento de sus obligaciones fiscales

Revista Visión Contable
La evasión de impuestos representa uno de los mayores retos a los que ha tenido que enfrentarse los gobiernos a nivel global, ya que es una problemática que no solo se vive en los países en vía de desarrollo sino también en los países desarrollados. Por
Ana Cristina Melguizo Betancur
doaj   +1 more source

La planificación tributaria internacional. The international tax planning

Retos, 2012
La planificación tributaria internacional se ha desarrollado fundamentada en la globalización y tiene su principal asidero en los múltiples beneficios que el propio legislador ha incorporado en la legislación, en su afán de atraer a los países inversión ...
Romeo Carpio Rivera
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

¿La política fiscal debe promoverse desde la Política Económica Colombiana?

Revista Científica Profundidad Construyendo Futuro, 2016
El resultado de aplicar la política fiscal en la política económica en Colombia, señala que las reformas tributarias, en principio no son enunciadas en las propuestas de los electos candidatos presidenciales, pero en la medida en que se pueda ejecutar ...
Patricia Pinilla Perez, Fabio Augusto Niño Lievano, David Andres Suárez Suárez, Alejandra Maria Gutierrez Espalza   +3 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

El malestar del ser:

Mutatis Mutandis: Revista Internacional de Filosofía, 2019
El artículo se propone leer los ensayos de Levinas: Algunas reflexiones sobre la filosofía del hitlerismo y De la evasión como dos capítulos de un mismo discurso en el cual el autor muestra cual pueden ser los peligros y los riesgos de un pensamiento ...
Matilde Orlando
doaj