Results 41 to 50 of about 167,053 (195)

Hacia el fomento de la cultura tributaria desde la primera infancia

Revista Activos, 2018
El presente artículo es resultado de la investigación dirigida hacia el tema de cultura tributaria desde la primera infancia, atendiendo lo anterior a que diferentes países en el mundo enfrentan problemas de recaudo de impuestos, a lo que no es ajena ...
María Ana Martina Chía Suárez, Juan Andrés Gómez Quiñónez, Cristian Camilo López Ruíz, Sergio Alonso Porras Mejía   +3 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Evasión de impuestos nacionales en Colombia: años 2001 - 2009

Revista Facultad de Ciencias Económicas, 2010
En este artículo se realiza una aproximación al tema de la evasión, se busca definir el concepto de evasión tributaria tomando como referencia aproximaciones económicas que hasta la fecha se han realizado. Inicialmente se exponen los diferentes conceptos;
ORLANDO DARÍO PARRA JIMENEZ, RUTH ALEJANDRA PATIÑO JACINTO   +1 more
doaj   +3 more sources

¿La política fiscal debe promoverse desde la Política Económica Colombiana?

Revista Científica Profundidad Construyendo Futuro, 2016
El resultado de aplicar la política fiscal en la política económica en Colombia, señala que las reformas tributarias, en principio no son enunciadas en las propuestas de los electos candidatos presidenciales, pero en la medida en que se pueda ejecutar ...
Patricia Pinilla Perez, Fabio Augusto Niño Lievano, David Andres Suárez Suárez, Alejandra Maria Gutierrez Espalza   +3 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

La planificación tributaria internacional. The international tax planning

Retos, 2012
La planificación tributaria internacional se ha desarrollado fundamentada en la globalización y tiene su principal asidero en los múltiples beneficios que el propio legislador ha incorporado en la legislación, en su afán de atraer a los países inversión ...
Romeo Carpio Rivera
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source