Results 41 to 50 of about 192,876 (233)
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Evasión tributaria y recaudación fiscal
Innovación Empresarial, 2021 Objetivo. La investigación tuvo por objetivo contribuir con el diagnóstico de la evasión tributaria del rubro hotelero en el distrito de Amarilis y su impacto en los ingresos fiscales. Métodos.
Julissa Jhenifer Rivera Presentación
doaj +1 more source
La evasión fiscal en el Ecuador [PDF]
, 2023 La evasión fiscal es definida como el no pago de una contribución; no hacer el pago de una contribución es semejante a esquivar el deber de cubrirla. Se trata de la violación de la ley que establece el deber de pagar al fisco lo que este órgano tiene
Vallejo Vega, María Jose
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Colindancias: Revista de la Red de Hispanistas de Europa CentralEn nuestro estudio partimos de la idea de que tanto Ana Blandiana como Corina Oproae narran, a través de procedimientos fantásticos, realistas o combinados, emociones y vivencias del comunismo rumano –percibidas contextual y subjetivamente, pero ...
Olivia Narcisa Petrescu
doaj +1 more source
Causas y consecuencias de la evasión tributaria
El presente trabajo se centró en la problemática de la evasión tributaria, un fenómeno que afecta la recaudación fiscal y el desarrollo sostenible de las políticas públicas.
Bloom Montrroza, Cristian Camilo +1 more
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Kairós, Revista de Ciencias Económicas, Jurídicas y AdministrativasLa evasión fiscal se ve influenciada por factores económicos, sociales y actitudinales. Aunque la teoría tradicional de la evasión tiene limitaciones, el estudio del comportamiento del contribuyente y su relación con la administración tributaria ha sido ...
Fausto Danilo Erazo Guijarro +1 more
doaj +1 more source