Results 51 to 60 of about 167,053 (195)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Evasión tributaria, una revisión
Revista Activos, 2019 El presente artículo tiene como temática la evasión tributaria, la cual es un problema mundial, de ahí su importancia y relevancia en investigación. En el presente artículo se realiza una revisión general sobre el comportamiento social, de valores y ...
Ruth Alejandra Patiño Jacinto +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
La auditoria y los niveles de evasión tributaria
Quipukamayoc, 2018 En nuestro país, la SUNAT viene haciendo grandes esfuerzos con el fin de orientar a todos aquellos contribuyentes que no cumplen con sus obligaciones fiscales frente al Estado, así mismo con aquellos que deben tributar y nunca lo han hecho.
Raúl Rengifo Lozano
doaj +1 more source
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
Revista de Estudos Literários da UEMS - REVELL, 2018 El presente artículo indaga en los lugares de enunciación que se configuran en los textos La desaparición del paisaje (2015) de Maximiliano Barrientos (1979), Génesis 4:12 (2016) de Adhemar Manjón (1981) y Autorretrato (2017) de Saúl Montaño (1985 ...
Magdalena González Almada
doaj
Kairós, Revista de Ciencias Económicas, Jurídicas y AdministrativasLa evasión fiscal se ve influenciada por factores económicos, sociales y actitudinales. Aunque la teoría tradicional de la evasión tiene limitaciones, el estudio del comportamiento del contribuyente y su relación con la administración tributaria ha sido ...
Fausto Danilo Erazo Guijarro +1 more
doaj +1 more source