Results 111 to 120 of about 50,299 (283)

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang   +8 more
wiley   +1 more source

Three-dimensional finite-time optimal cooperative guidance with integrated information fusion observer

Defence Technology
Intercepting high-maneuverability hypersonic targets in near-space environments poses significant challenges due to their extreme speeds and evasive capabilities.
Yiao Zhan, Linwei Wang, Di Zhou
doaj   +1 more source

The Effects of Target and Missile Characteristics on Theoretical Minimum Miss Distance for a Beam-Rider Guidance System in the Presence of Noise [PDF]

, 1959
A study has been made to determine the relative importance of those factors which place an inherent limitation on the minimum obtainable miss distance for a beam-rider navigation system operating in the presence of glint noise and target evasive maneuver.
Stewart, Elwood C., Druding, Frank, Nishiura, Togo   +2 more
core  

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Varying Speed Cooperative Differential Game Guidance Laws With Intercept Angle Constraints

International Journal of Aerospace Engineering
For intercepting modern highly maneuvering targets, considering the velocity variation of adversaries, a varying speed cooperative differential games guidance method is proposed, which can enable multiple air-to-air missiles to intercept targets at a ...
Chao Xiahou, Hao Zhou, Wanchun Chen, Liang Yang   +3 more
doaj   +1 more source

A Residual PPO Algorithm Based on Blended Generalized Proportional Navigation for Terminal UAV Interception in Three-Dimensional Asymmetric Confrontations

Drones
Unauthorized low-altitude UAVs can challenge conventional fixed-parameter interception algorithms through agile maneuvers. This study develops a three-dimensional one-on-one terminal-interception simulation environment that incorporates protected-zone ...
Lei Zuo, Ying Wang, Jialu Liu, Yu Lu, Ruiwen Gu   +4 more
doaj   +1 more source

Gregarious Behaviour of Evasive Prey [PDF]

Gregarious behavior of potential prey was explained by Hamilton (1971) on the basis of risk-sharing: The probability of being picked up by a predator is small when one makes part of a large aggregate of prey.
Avner Shaked, Ilan Eshel, Emilia Sansone
core  

ROS Self‐Supply Nanoplatform Based on Fenton Catalyst for Chemodynamic and Immunotherapy: Reprogramming Cold Tumor Into Hot Tumor in Cancer Treatment

Advanced Science, EarlyView.
A multifunctional HA‐conjugated nanoplatform (HA‐PGMC) integrates CuO2, glucose oxidase, and mil‐100 to enable cascade catalytic ROS generation in tumor microenvironments. This self‐supplying ROS strategy induces immunogenic cell death, reprograms “cold” tumors into “hot” ones, and synergizes with PD‐L1 blockade, achieving potent chemodynamic ...
Man Lung Lee, Jack Chun Hin Chen, Wai Wing Cheng, Kwan Yee Lau, Hiu Yee Kwan, Ngar‐Yun Ellen Poon, Hung‐Wing Li   +6 more
wiley   +1 more source

Defining Preventable Boundaries in Automated Driving Systems: A Driver Behavior Model for Scenario-Based Assessments

IEEE Access
This study presents a quantitative framework for defining preventable boundaries in scenario-based assessments of Automated Driving Systems (ADS) grounded in a novel driver behavior model.
Sou Kitajima, Husam Muslim, Ryosuke Katoh, Joohyeong Lee, Hideaki Satoh, Koichiro Ozawa, Eiichi Kitahara, Hiroki Nakamura   +7 more
doaj   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source