Results 61 to 70 of about 955,872 (288)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

The languages of Malta

, 2017
The purpose of this volume is to present a snapshot of the state of the art of research on the languages of the Maltese islands, which include spoken Maltese, Maltese English and Maltese Sign Language. Malta is a tiny, but densely populated country, with
Gatt, Albert, Camilleri, Maris, Krug, Manfred, Paggio, Patrizia, Puech, Gilbert, Galea, Luke, Ussishkin, Adam, Grech, Sarah, Spagnol, Michael, Azzopardi-Alexander, Marie, Vella, Alexandra, Lucas, Christopher, Sönning, Lukas, Fabri, Ray, Schembri, Natalie   +14 more
core   +1 more source

“You are so far away, you don't even exist...”: Negative Constructions in the Poetic Language of Mykola Vinhranovsky

Вісник Харківського національного університету імені В. Н. Каразіна. Серія Філологія. Vìsnik Harkìvsʹkogo nacìonalʹnogo unìversitetu ìmenì V.N. Karazìna. Serìâ Fìlologìâ.
Mykola Vinhranovsky quite actively uses negation in his poetic language, the systematic study of which is relevant because it allows us to trace the unique nature of the writer's world perception and linguistic thinking.
Yuliya Kalashnyk
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Crossroads between contrastive linguistics, translation studies and machine translation: TC3-II

, 2017
Contrastive Linguistics (CL), Translation Studies (TS) and Machine Translation (MT) have common grounds: They all work at the crossroad where two or more languages meet.
Seiss, Melanie, Czulo, Oliver, Thunes, Martha, Riezler, Stefan, Zinsmeister, Heike, Hartung, Matthias, Gylling, Morten, Kremer, Gerhard, Dragsted, Barbara, Hansen-Schirra, Silvia, Padó, Sebastian, Korzen, Iørn, Steiner, Erich, Carl, Michael, Dipper, Stefanie   +14 more
core   +1 more source

Language Inclusion for Boundedly-Ambiguous Vector Addition Systems is Decidable [PDF]

Logical Methods in Computer Science
We consider the problems of language inclusion and language equivalence for Vector Addition Systems with States (VASS) with the acceptance condition defined by the set of accepting states (and more generally by some upward-closed conditions). In general,
Wojciech Czerwiński, Piotr Hofman
doaj   +1 more source

Even linear simple matrix languages: formal language properties and grammatical inference

Theoretical Computer Science, 2002
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

A Critical Review of Kurdish Language Branches Based on Geographical Residency

پژوهشنامه ادبیات کردی, 2020
There is no unanimous agreement among linguists and sociolinguists regarding the definition and distinction among terms and concepts of language, dialect and accent.
Hiwa Weisi
doaj   +1 more source