Results 61 to 70 of about 8,541,152 (269)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

La « Harangue faicte au Roy par Itapoucou » : un discours politique en langue tupi (France, XVIIe)

Corpus: Archivos Virtuales de la Alteridad Americana, 2014
The speech addressed to king of France Louis XIII, in 1614, by an Indian from Maragnan as ambassador, allows us to observe the language and rhetoric tupi of this distant time, and especially to study the way this text in original language takes place in ...
Géraldine Méret
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Third language acquisition: Age, proficiency and multilingualism [PDF]

, 2020
This book deals with the phenomenon of third language (L3) acquisition. As a research field, L3 acquisition is established as a branch of multilingualism that is concerned with how multilinguals learn additional languages and the role that their ...
Gudmundson, Anna, Sleeman, Petra, Sánchez, Laura, Sciutti, Sandro, Bardel, Camilla, Salaberry, Rafael, Muñoz, Carmen, Stadt, Rosalinde, Pfenninger, Simone E., Hulk, Aafke   +9 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Serawai sebagai bahasa minoritas (sebuah kajian ekolinguistik dalam pembelajaran dan pemertahanan)

Diglosia
The purpose of this research is to analyze the role of the environment in the learning and preservation of the Serawai language, also known as ecolinguistics.
Andestend Andestend, Salati Asmahasana, Luzi Pebriani, Gita Putri Amalia Shaliha   +3 more
doaj   +1 more source

Word order variation in Plautus

Linguistica, 2005
Unlike some other language phenomena, word order is an unavoidable feature of an utterance. It can be observed in any language as it is always necessary to arrange words (provided the language in question discerns such meaningful entities) in some ...
Matjaž Babič
doaj   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

“You are so far away, you don't even exist...”: Negative Constructions in the Poetic Language of Mykola Vinhranovsky

Вісник Харківського національного університету імені В. Н. Каразіна. Серія Філологія. Vìsnik Harkìvsʹkogo nacìonalʹnogo unìversitetu ìmenì V.N. Karazìna. Serìâ Fìlologìâ.
Mykola Vinhranovsky quite actively uses negation in his poetic language, the systematic study of which is relevant because it allows us to trace the unique nature of the writer's world perception and linguistic thinking.
Yuliya Kalashnyk
doaj   +1 more source