Results 71 to 80 of about 955,872 (288)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Justifications for a Discontinuity Theory of Language Evolution

Biolinguistics, 2018
In Chapter 6 of Biological Foundations of Language, Lenneberg argues against continuity theories of language evolution, which claim that language evolved from simpler communication systems.
Callum Hackett
doaj   +1 more source

THE SOCIOLINGUISTIC SITUATION IN PRESENT-DAY MONTENEGRO – SERBIAN STUDIES, MONTENEGRIN STUDIES

Концепт: философия, религия, культура, 2018
This article deals with relevant processes related to language issues in Montenegro. The consequence of these ideological, social, anti-scientific and scientific processes is the presence of three Sciences about the language of the state – forming people
D. Bojović
doaj   +1 more source

On Some Complexity Results for Even Linear Languages

CoRR
16 pages, no figure.
openaire   +2 more sources

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Italian dialects and language contact

Isogloss
In this short introduction to the Special Issue of Isogloss, dedicated to language contact involving Italian dialects, we show that the study of the non-standard varieties of Italy has a great heuristic potential, which is at least threefold: (i ...
Mario Wild, Stefano Negrinelli, Federica Breimaier, Stefano Cristelli, Michele Loporcaro, Tania Paciaroni   +5 more
doaj   +1 more source

Sprachbewusstheit – Sprachreflexion – Sprachkritik – Sprachpraxis – Sprachspiel: Didaktische Perspektiven auf die Auseinandersetzung von Kindern mit tradierten sprachlichen Formen

Linguistik Online, 2016
Children enjoy playing with language, even when they are as young as four years of age. Their playful practice can be seen as dealing with linguistic rules and conventions critically.
Helga Andresen
doaj   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Evaluating the capability of base and large-scale language models for multilingual sarcasm detection [PDF]

PeerJ Computer Science
Even though natural language understanding has made significant progress, language models still struggle to grasp sarcasm, a complex linguistic phenomenon that is influenced by cultural and contextual differences.
Girma Yohannis Bade, Olga Kolesnikova, Jose Luis Oropeza, Moein Shahiki Tash   +3 more
doaj   +2 more sources