Results 71 to 80 of about 5,113 (218)
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Diminishing mangrove forest structures in Davao City, Philippines
The decline of mangrove coverage across the Philippines to 50% of its original coverage in present years has, led to significant reductions of ecological functions to fisheries and benefits to man.
John Glen P. Seniel +2 more
doaj +1 more source
Criteria for Comparison of Bands in Even–Even Nuclei
A cluster model gives a satisfactory reproduction of normal deformed (ND) ground state bands in a wide range of even-even nuclei. We show here that the fractional change of the transition energies in two bands is closely related to the fractional change in the corresponding reduced masses. We compare our predictions to data on ground state ND bands for
Buck, B, Merchant, A, Perez, S
openaire +2 more sources
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Intruder states in even-even Te nuclei
Abstract We use a systematic analysis of experimental data for 112–128Te to provide evidence for existence of intruder excitations in 116–124Te. We augment our analysis with mixed configuration IBM-2 calculations and find good agreement between these calculations and both experimental energy-level systematics and transition rates.
Rikovska, J +3 more
openaire +2 more sources
Reconstructing enzyme evolution by protein engineering
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
We examined the species abundance distribution (SAD) of plant communities in: (1) a wet grassland, waterlogged throughout most of the year; (2) a seasonal savanna, with an annual dry season; and (3) a hyperseasonal savanna, with alternating drought and ...
Igor Aurélio Silva +2 more
doaj +1 more source

