Results 81 to 90 of about 41,806 (268)
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Composition and diversity of woody plant species in agro-ecosystems of Uluguru Mountains, Tanzania
Forest Science and TechnologyWoody plant species are important components of agro-ecosystems that determine their productivity and biodiversity conservation in tropical mountain landscapes.
Lisa Mbaruku +2 more
doaj +1 more source
Discrete Mathematics, 1991 Even self-orthogonal codes over \(GF(2^ m)\) are introduced. If \(GF(2^ m)\) is identified with \((GF(2))^ m\) using a self-complementary basis, such codes become binary codes in which all weights are multiples of four. Extended Reed-Solomon codes of rate \(\leq 1/2\) turn out to be even.
openaire +3 more sources
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Acta Scientiarum: Biological Sciences, 2008 Com o objetivo de analisar as mudanças de curta duração da comunidadefitoplanctônica, em um braço do reservatório de Rosana, formado pelo ribeirão do Corvo, foram coletadas amostras de fitoplâncton total em tréplicas à subsuperfície da região pelágica. O
Paula Aparecida Federiche Borges +1 more
doaj
Application of Landscape Ecology Indices in Monitoring and Assessing Desertification (Case Study: Omrani Area of Gonabad) [PDF]
جغرافیا و پایداری محیط, 2018 Desertification is one of the most important degenerative phenomena in many arid and semi-arid regions. Climate change and human activities have led to the increase of desertification and desert development in these areas.
Masoud Eshghizadeh
doaj