Results 121 to 130 of about 23,278 (245)

Distinctive neurophysiological correlates of sound onset and offset perception in humans

The Journal of Physiology, EarlyView.
Abstract figure legend Electroencephalography (EEG) recordings were obtained from participants listening to successive pairs of 1‐2 s noises in a silent background (Study 1) or successive pairs 1‐2 s silent gaps in a noise background (Study 2). Participants heard the same stimuli in the context of either a duration discrimination task (identifying ...
Fatima Ali, Gabriela Bury, Adèle Simon, Jennifer F. Linden   +3 more
wiley   +1 more source

Targeting EZH2 in Cancer: From Molecular Mechanisms to Clinical Translation

MedComm – Oncology, Volume 5, Issue 2, June 2026.
The abnormal overexpression or gain‐of‐function mutations of EZH2 play a significant role in cancer occurrence and progression, highlighting the importance and potential of EZH2 as a cancer biomarker. Therefore, screening for effective and safe small‐molecule inhibitors, degraders, and natural compounds targeting EZH2 through preclinical cancer models ...
Xi Zhong, Jieni Li, Mingxuan Pan, Xiaoxue Ke, Hongjuan Cui   +4 more
wiley   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, Volume 20, Issue 5, Page 1364-1378, May 2026.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Potenciais evocados auditivos de longa latência em campo sonoro em crianças audiologicamente normais

Audiology: Communication Research
RESUMO Objetivo: Caracterizar os Potenciais Evocados Auditivos de Longa Latência (PEALL) (P1, N1, P2, N2, P300) em campo sonoro, em crianças audiologicamente normais, bem como verificar a estabilidade destes potenciais.
Carla Gentile Matas, Fernanda Bicalho Lima Silva, Barbara Carrico, Renata Aparecida Leite, Fernanda Cristina Leite Magliaro   +4 more
doaj   +1 more source

BCR::ABL1‐Induced Enhancer Reprogramming Uncovers Hypersensitivity of Ph+B‐ALL Cells to Enhancer‐Targeting Drugs

Advanced Science, Volume 13, Issue 25, 4 May 2026.
Ng et al. show that the BCR::ABL1 kinase that drives the lymphoid leukemia Ph+B‐ALL modulates enhancer function by coopting signaling‐inducible transcription factors such as MYC, STAT5, and ETV5. BCR::ABL1 thereby promotes the transcriptional program driving and defining this leukemia and renders Ph+B‐ALL cells hypersensitive to enhancer‐inhibiting ...
Han Leng Ng, Trudy Lee Glaser, Jintao Zhu, Mark E. Robinson, Kadriye N. Cosgun, Valeriya Malysheva, Ozgen Deniz, Nicholas T. Crump, Kaiyue Helian, Andrew J. Innes, Richard Burt, Li Sun, George John, Haibin Zhou, Atsunori Kaneshige, Longchuan Bai, Shaomeng Wang, Mikhail Spivakov, Markus Müschen, Niklas Feldhahn   +19 more
wiley   +1 more source

The N2-P3 complex of the evoked potential and human performance [PDF]

The N2-P3 complex and other endogenous components of human evoked potential provide a set of tools for the investigation of human perceptual and cognitive processes. These multidimensional measures of central nervous system bioelectrical activity respond
Cohen, Ronald A., Odonnell, Brian F.
core   +1 more source

Transcranial Alternating Current Stimulation at the Individual Alpha Frequency Shows Potential Value in Improving Working Memory in Healthy Participants

Brain and Behavior, Volume 16, Issue 5, May 2026.
IAF‐tACS significantly improves high‐load WM performance in healthy participants. The increased P300 amplitude in the frontocentral region during high‐load tasks suggests that parietal cortex stimulation may enhance cognitive resource allocation in the prefrontal area by modulating the frontoparietal network, which could be a key mechanism for its WM ...
Zhiqiang Wang, Yulan Gao, Menglin Han, Longting Hu, Kangling Wang   +4 more
wiley   +1 more source

Transcriptomic and DNA Methylation Profiles of Alternative Aphid Morphs and Genotypes

Ecology and Evolution, Volume 16, Issue 5, May 2026.
Graph showing the correlation between differentially expressed genes and differentially methylated genes. There is no correlation between gene expression and DNA methylation level in pea aphid polyphenism. ABSTRACT Pea aphids can develop alternative morphs when exposed to stressful conditions, showing differences between genotypes in their stress ...
Zhe Yang Yim, Christopher Murgatroyd, Reinmar Hager   +2 more
wiley   +1 more source

Evaluation of cognitive functions in Parkinson’s patients without dementia with auditory event related potential (P300) [PDF]

Düşünen Adam Psikiyatri ve Nörolojik Bilimler Dergisi, 2014
Objective: Idiopathic Parkinson’s disease is a clinical situation characterized by akinesia, rigidity, and tremor, and results from the degeneration of the dopaminergic nervous system.
suna sarikaya, tahir kurtulus yoldas, nese gungor yavasoglu   +2 more
doaj  

P300 event-related potential in children with hypothyroidism

Journal of Family Medicine and Primary Care
ABSTRACT Background: Hypothyroidism is a common endocrine disorder, which adversely affects the developing central nervous system in the pediatric population. Despite treatment, patients may continue to experience neurological impairments such as cognitive dysfunction. P300 is an event-related
Ravi, Naveen, Bharshankar, Rajay N., Hulke, Sandip M., Thakre, Avinash Eknath, Wakode, Santosh Laxman, Subba Krishna, N., John, Nitin Ashok, Taranikanti, Madhuri, Kalpana, M., Prafull, K., Daulatabad, Vandana S., Singhal, Anish, Ganji, Vidya, Umesh, Madhusudhan, Gaur, Archana   +14 more
openaire   +2 more sources