Results 141 to 150 of about 10,705,458 (263)

Mechanisms of Exercise Training in Ameliorating Cognitive Function in Patients With Depression: A Narrative Review of Molecular Targets and Clinical Prescriptions

European Journal of Sport Science, Volume 26, Issue 11, November 2026.
ABSTRACT Depression is frequently accompanied by core cognitive impairments, notably in executive function and memory. Although the ameliorative effects of exercise training have been widely corroborated, the evidence regarding its underlying mechanisms remains fragmented. To provide a comprehensive and integrated view, this review proposes a testable,
Zhaohui Guo, Lingling Dong, Jessie J. X. Lin, Yanping Duan, Weizhi Liu, Wanting Jiang, Cong Liu, Shuqi Jia, Yagang Song, Feng Ding, Zhenwen Xie, Mingyue Yin, Kang Zhu, Xiaochen Ma, Peng Wang, Chen Wei, Felipe Barreto Schuch, Xing Wang   +17 more
wiley   +1 more source

Identification of MEF2A, MEF2C, and MEF2D interactomes in basal and Fsk‐stimulated mouse MA‐10 Leydig cells

Andrology, Volume 14, Issue 8, Page 2401-2418, November 2026.
Abstract Background Myocyte enhancer factor 2 transcription factors regulate essential transcriptional programs in various cell types. The activity of myocyte enhancer factor 2 factors is modulated through interactions with cofactors, chromatin remodelers, and other regulatory proteins, which are dependent on cell context and physiological state.
Karine de Mattos, Marie‐Pier Scott‐Boyer, Arnaud Droit, Robert S. Viger, Jacques J. Tremblay   +4 more
wiley   +1 more source

Seizure Frequency Affects Event-Related Potentials (P300) in Epilepsy

, 2009
To analyse the effect of epilepsy an P300 event-related potentials we studied 27 patients with idiopathic generalized epilepsy (IGE), 13 patients with temporal lobe epilepsy (TLE) and 60 normal controls.
CHEN, RONG-CHI;TSAI, SONG-YEN;CHANG, YANG-CHYUAN;LIOU, HORNG-HUEI, 陳榮基;蔡松彥;張楊全;劉宏輝   +1 more
core  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, Volume 20, Issue 10, Page 2424-2448, October 2026.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, Volume 20, Issue 10, Page 2533-2566, October 2026.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, Volume 20, Issue 10, Page 2449-2465, October 2026.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

A Neurophysiolgical study on P300 component of event-related potentials in Hakim-Adams syndrome.

, 1993
Exploration of the variability of P300 event-related potentials in patients affected by Hakim-Adams ...
M. Panarelli, QUATRALE, Rocco, V.C. Monetti, ROCCELLA, Paolo, SERRA, GIANNI, TRAPELLA, Giorgio, GRANIERI, Enrico Gavino Giuseppe   +6 more
core  

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, Volume 20, Issue 10, Page 2466-2489, October 2026.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

A longitudinal, event-related potential pilot study of adult obsessive-compulsive disorder with 1-year follow-up

Neuropsychiatric Disease and Treatment, 2016
Kazuhiko Yamamuro,1 Koji Okada,2 Naoko Kishimoto,1 Toyosaku Ota,1 Junzo Iida,3 Toshifumi Kishimoto1 1Department of Psychiatry, Nara Medical University School of Medicine, 2Department of Psychiatry, Jingumaecocorono-Clinic, 3Faculty of Nursing, Nara ...
Yamamuro K, Okada K, Kishimoto N, Ota T, Iida J, Kishimoto T   +5 more
doaj  

TRAF6 Lactylation in Glycolytic Macrophages Drives NF‐κB Signaling and M1 Polarization During Orthodontic Tooth Movement

Advanced Science, Volume 13, Issue 55, 5 October 2026.
Schematic diagram showing compressive stress triggers glycolytic reprogramming and lactate accumulation in macrophages. Lactate mediates TRAF6 lactylation at K171/K180 dual sites, which enhances its K63‐linked ubiquitination to activate the NF‑κB pathway and promote M1 polarization. This cascade drives orthodontic tooth movement (OTM) and alveolar bone
Xinyi He, Guodong Zhao, Yun Hu, Wenya Bai, Hao Tan, Shuai Yuan, Sihan Yang, Ye Zhu, Xiaohui Xu, Leilei Zheng   +9 more
wiley   +1 more source