Results 141 to 150 of about 10,047 (252)

A Circuit of Mechanically Regulated Transcription Factors Balances Regenerative and Fibrotic Memory of Mesenchymal Stromal Cells

open access: yesAdvanced Science, Volume 13, Issue 37, 3 July 2026.
Producing MSCs on rigid culture substrates induces a scar‐making phenotype, jeapordizing therapeutic success. ‘Tissue‐soft’ surfaces prevent MSC fibrogenesis and preserve regenerative traits. An epigenetic network, driven by HOXA11 and SALL1, maintains ‘soft memory’ by keeping chromatin open in relaxed MSCs, promoting anti‐fibrotic programs.
Fereshteh Sadat Younesi   +7 more
wiley   +1 more source

Neurophysiological Differentiation of Conversion to Alzheimer's Disease: Longitudinal Changes in P300 Amplitude as an Indicator of Mild Cognitive Impairment Progression

open access: yesBrain and Behavior, Volume 16, Issue 7, July 2026.
Longitudinal EEG recordings showed reduced P300 amplitudes in mild cognitive impairment, with the lowest values observed in individuals who progressed to Alzheimer's disease. Central P300 measures demonstrated strong discriminative performance and may represent an accessible electrophysiological marker associated with disease progression.
Yağmur Özbek, Görsev G. Yener
wiley   +1 more source

P300 WAVE CONFIRMATION IN PATIENTS WITH PARKINSON’S DISEASE

open access: yesZdravniški Vestnik, 2001
Background. Mild to moderate cognitive dysfunction is a frequent complaint of patients with Parkinson’s disease, though the clinical picture of dementia is rarely reported.Methods.
Marko Pišljar   +2 more
doaj  

Quantitative Control of Transposable Elements: From Genome Plasticity to Immune Regulatory Circuits

open access: yesCell Biochemistry and Function, Volume 44, Issue 7, July 2026.
ABSTRACT Transposable elements (TEs) constitute nearly half of the human genome and are increasingly recognized as context‐dependent regulators of genome function rather than passive repetitive DNA. This Review synthesizes classical and recent evidence on TE biology, including TE classification, mechanisms of mobilization, host restriction pathways ...
Irving Jesús Reyes‐Barragán
wiley   +1 more source

Research on the Mechanism of Natural Products Acting on Chronic Obstructive Pulmonary Disease

open access: yesFood Science &Nutrition, Volume 14, Issue 7, July 2026.
This figure illustrates that approximately 80 natural compounds exert therapeutic effects against chronic obstructive pulmonary disease by targeting pathological mechanisms such as airway inflammation, oxidative stress, airway remodeling, mucus hypersecretion, emphysema, protease–antiprotease imbalance, apoptosis, and autophagy.
Shuna Wei, Xiaoju Liu
wiley   +1 more source

Is brain activity observable that leads to an evaluation of a probability of 0.5 that is different from 0.5 in binary lottery choices? [PDF]

open access: yes
This paper focuses on the problem of probability weighing in the evaluation of lotteries. According to Prospect Theory a probability of 0.5 has a weight of smaller than 0.5.
Bodo Vogt   +3 more
core  

Multiple myeloma: A tale of deregulated transcription factors

open access: yesHemaSphere, Volume 10, Issue 7, July 2026.
Abstract A comprehensive understanding of the molecular mechanisms underlying multiple myeloma (MM) pathogenesis is essential for developing therapeutic strategies that overcome disease heterogeneity and treatment relapse. In this review, we focus on transcription factors (TFs), key regulators of gene expression that play critical roles in normal ...
Nahia Gómez‐Echarte   +5 more
wiley   +1 more source

Osimertinib Resistance in EGFR‐Mutated Non–Small Cell Lung Cancer: Mechanisms and Therapeutic Strategies

open access: yesMedComm, Volume 7, Issue 7, July 2026.
This review illustrates the key mechanisms of osimertinib resistance in EGFR‑mutant NSCLC, including EGFR‑dependent mutations, bypass pathway activation, and SMARCA4‑mediated epigenetic regulation. We also summarize emerging targeted therapies and future perspectives to overcome EGFR‑TKI resistance.
Junfeng Guo, Qiuyuan Wen, Songqing Fan
wiley   +1 more source

Multichannel EEG : towards applications in clinical neurology. [PDF]

open access: yes, 2008
Electroencephalogram (EEG) measures the electric activity produced by the brain with electrodes placed on the scalp. It is used for monitoring or as diagnostic tool for neurological disorders. In practice a maximum of 21 electrodes are generally used for
Wassenberg, Wilhelmina Johanna Gerarda van de   +1 more
core  

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