Results 161 to 170 of about 8,670,117 (259)

Understanding and addressing resistance to IMiDs immunomodulatory compounds in multiple myeloma

open access: yesThe FEBS Journal, Volume 293, Issue 17, Page 5121-5139, September 2026.
IMiDs are pivotal in the treatment of multiple myeloma. Mechanisms of resistance comprise cell intrinsic and extrinsic pathways, involving tumour microenvironment, immune cell dysfunction, CRBN‐dependent and independent genetic drivers and epigenetic changes.
Maria‐Cynthia Fuentes‐Lacouture   +3 more
wiley   +1 more source

An event-related potentials account of brain predictive coding. [PDF]

open access: yesCogn Neurodyn
Gómez CM   +5 more
europepmc   +1 more source

P53 Competitively Binds P300 to Suppress HIF‐1α/TFRC‐Mediated Ferroptosis and Promote Doxorubicin Resistance in Breast Cancer

open access: yesThe FASEB Journal, Volume 40, Issue 16, 31 August 2026.
Upregulated P53 competitively binds P300, reducing its availability to HIF‐1α and thereby decreasing HIF‐1α/P300 co‐occupancy and transcriptional activation at the TFRC promoter. The resulting reduction in TFRC‐dependent iron uptake weakens Fenton reactions, lipid peroxidation, and ferroptosis, ultimately promoting doxorubicin resistance in breast ...
Xiaojie Yu   +5 more
wiley   +1 more source

Nonlinearities and Switch‐Like Behavior in Gene Expression: From Genetics to Biochemistry and Back

open access: yesThe FASEB Journal, Volume 40, Issue 16, 31 August 2026.
Modest changes in transcription‐factor or chromatin‐regulator dosage can have disproportionate effects when gene‐regulatory systems operate near nonlinear thresholds. Sigmoidal input–output relationships, chromatin and cofactor recruitment, and changes in threshold position or response steepness provide molecular routes by which quantitative dosage ...
Reiner A. Veitia, James A. Birchler
wiley   +1 more source

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