Results 41 to 50 of about 605,381 (249)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
The Life and Death of Frames: Dynamics of Media Frame Duration
International Journal of Communication, 2016 Media framing scholars have long examined why journalists select certain frames over others at a given point. However, we know much less about why certain frames persist over time in the media while others fade away and still others disappear very ...
Rebekah Tromble, Michael Meffert
doaj
Frontiers in SociologyIntroductionAccess to the labor market is influenced by various socio-economic factors, including social class and education. In Italy, these elements play a crucial role in determining employment opportunities and career trajectories. This study aims to
Davide Bussi +3 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
The partnership context of first parenthood – and how it varies by parental class and birth cohort in the United Kingdom [PDF]
Demographic ResearchBACKGROUND: Family background strongly shapes when and how people have their first child, with potential consequences for inequality. In the United Kingdom, non-marital births have risen, yet little is known about how parental class drives these patterns.
Alessandro Di Nallo
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Event history analysis and the cross-section [PDF]
Statistics in Medicine, 2006 Examples are given of problems in event history analysis, where several time origins (generating calendar time, age, disease duration, time on study, etc.) are considered simultaneously. The focus is on complex sampling patterns generated around a cross-section. A basic tool is the Lexis diagram.
openaire +2 more sources
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Demographic Research, 2014 Background: Family composition and household dynamics, both in early and in later life, influence individual health and longevity. Both positive and negative effects can be expected in terms of sibling size and composition.
Robyn Donrovich +2 more
doaj +1 more source