Results 131 to 140 of about 3,391,200 (289)
Event structure of problem situations
Вестник Самарского государственного технического университета. Серия: Психолого-педагогические науки, 2018 In the paper the notion of “situation” is analyzed in linguistic and psychological context. The review of approaches to the definition of situations is presented.
Viсtoria V. Dobrova, Helen V. Butina
doaj
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Topological Properties of Event Structures
Electronic Notes in Theoretical Computer Science, 2009 Motivated by the nice labelling problem for event structures, we study the topological properties of the associated graphs. For each n⩾0, we exhibit a graph Gn that cannot occur on an antichain as a subgraph of the graph of an event structure of degree n .
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Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Joint event extraction model based on dynamic attention matching and graph attention networks
Scientific ReportsEvent extraction is one of the important processes in event knowledge graph construction. However, extant event extraction models are confronted with the challenge of handling vague and unfamiliar event trigger words as well as noise that is prevalent in
Jiajun Cheng +4 more
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RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
An introduction to event structures
DAIMI Report Series, 1989 Event structures are models of processes as events constrained by relations of consistency and enabling. These notes are intended to introduce the mathematical theory of event structures, show how they are related to Petri nets and Scott domains, and how they can be used to provide semantics to programming languages for parallel processes as well as ...
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COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source