Results 121 to 130 of about 15,467,810 (252)
The Journal for Transdisciplinary Research in Southern AfricaThis study reports on an online transdisciplinary institutional mentoring initiative, the Sisonke Supervision Mentoring Programme. In 2024, a team of three established supervisors mentored a cohort of seven emerging supervisors over a period of 12 weeks.
Janet Condy +6 more
doaj +1 more source
How are missing data in covariates handled in observational time-to-event studies in oncology? A systematic review. [PDF]
BMC Med Res Methodol, 2020 Carroll OU, Morris TP, Keogh RH.
europepmc +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
, 2018 The growth path of event studies as an emergent field of study has been documented in a number of reviews and summations of the extant literature to study key topics of research interest, identify gaps in the prevailing research agenda, and map progress ...
Lockstone-Binney, L +1 more
core +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
New methodology for event studies in Bonds [PDF]
The new methodology to study the impact of corporate events on bonds is comprised of a sampling technique and regression model. The method is different from standard approaches, motivated by the belief that event impact should be reflected in levels of ...
Bell, Peter N
core
Shared Event Composition/Decomposition in Event-B
, 2010 The construction of specifications is often a combination of smaller sub-components. Composition and decomposition are techniques that support reuse and allow us to formally combine sub-components through refinement steps while reusing their properties ...
Silva, Renato, Butler, Michael
core +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source