Results 141 to 150 of about 15,467,810 (252)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

PREFACE - Pacific Neogene event studies for the 21st century

Revista Mexicana de Ciencias Geológicas, 2019
Proceedings of the VII International Congress on Pacific Neogene Stratigraphy, Mexico City, October 4-6, 1999.  Preface This special volume presents contributions from the VII International Congress on Pacific Neogene Stratigraphy, held at the ...
Ryuichi Tsuchi, John A. Barron, Adolfo Molina-Cruz   +2 more
doaj  

Real-world Performance of Meta-analysis Methods for Double-Zero-Event Studies with Dichotomous Outcomes Using the Cochrane Database of Systematic Reviews. [PDF]

J Gen Intern Med, 2019
Ren Y, Lin L, Lian Q, Zou H, Chu H.
europepmc   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Measures of follow-up in time-to-event studies: Why provide them and what should they be? [PDF]

Clin Trials, 2015
Betensky RA.
europepmc   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

BC Studies 2017 conference poster

, 2016
Poster for (Un)setting British Columbia - BC Studies 2017 conference. Conference date: May 4 - 6, 2017.
BC Studies
core  

The Role of Double-Zero-Event Studies in Evidence Synthesis: Evaluating Robustness Using the Fragility Index. [PDF]

J Eval Clin Pract
Wang Z, Xing X, Mun EY, Wu C, Lin L.
europepmc   +1 more source

Recognizing the problem of delayed entry in time-to-event studies: Better late than never for clinical neuroscientists. [PDF]

Ann Neurol, 2015
Betensky RA, Mandel M.
europepmc   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source