Results 41 to 50 of about 164,772 (264)

The application of event tree analysis in a work accident at maintenance operations

MATEC Web of Conferences, 2017
Event tree analysis is an inductive method, which involves determining the events flowing from the failure of a component or part of the system. Starting from an initiator event or an origin failure, the event tree analysis allows the estimation of ...
Mareş Radu, Stelea Mihai Popescu
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Research and development of probabilistic risk assessment methodology for combination event of low temperature and snow

Nihon Kikai Gakkai ronbunshu, 2016
The objective of this study is to develop probabilistic risk assessment (PRA) methodology for combination event of low temperature and snow by focusing on decay heat removal system (DHRS) of sodium-cooled fast reactor.
Hiroyuki NISHINO, Hidemasa YAMANO, Kenichi KURISAKA   +2 more
doaj   +1 more source

The Use of a Fault Tree Analysis (FTA) in the Operator Reliability Assessment of the Critical Infrastructure on the Example of Water Supply System

Energies, 2022
Background: Specialist literature indicates a large share of the human factor among the causes of failure of technical systems at the level of 70 to 90%, which depends on the sector studied.
Krzysztof Boryczko, Dawid Szpak, Jakub Żywiec, Barbara Tchórzewska-Cieślak   +3 more
doaj   +1 more source

Assessing railway accident risk through event tree analysis

, 2019
Railway safety is an important issue since the safety of passengers, employees, road users and residents in the area of railway can be affected when railway accidents happen.
Masnita Misiran, Misiran, Masnita, Nurul Faziera Khairul Adlee, Hasimah Sapiri, Mustafa Khalid, Nur Izyan, Sapiri, Hasimah, Khairul Adlee, Nurul Faziera, Nur Farah Najeeha Najdi, Nur Izyan Mustafa Khalid, Najdi, Nur Farah Najeeha   +9 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Risk Assessment of Hydrogen Production Station Equipment Based on Event Tree Cascading Fault Deduction and Evidential Reasoning

发电技术
The hydrogen production station system is complex and vulnerable to external attacks, causing cascading failures and serious safety accidents. The cascading failure deduction method based on event tree was adopted to determine the consequences and ...
LIU Yucheng, YANG Yuan, HU Yuhao, LI Yuhang, ZHAO Zitai, MA Zhiyong, DONG Yuliang   +6 more
doaj   +1 more source

Biologically feasible gene trees, reconciliation maps and informative triples

Algorithms for Molecular Biology, 2017
Background The history of gene families—which are equivalent to event-labeled gene trees—can be reconstructed from empirically estimated evolutionary event-relations containing pairs of orthologous, paralogous or xenologous genes.
Marc Hellmuth
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source