Results 51 to 60 of about 1,082,135 (250)

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Risk Assessment of Hydrogen Production Station Equipment Based on Event Tree Cascading Fault Deduction and Evidential Reasoning

发电技术
The hydrogen production station system is complex and vulnerable to external attacks, causing cascading failures and serious safety accidents. The cascading failure deduction method based on event tree was adopted to determine the consequences and ...
LIU Yucheng, YANG Yuan, HU Yuhao, LI Yuhang, ZHAO Zitai, MA Zhiyong, DONG Yuliang   +6 more
doaj   +1 more source

Biologically feasible gene trees, reconciliation maps and informative triples

Algorithms for Molecular Biology, 2017
Background The history of gene families—which are equivalent to event-labeled gene trees—can be reconstructed from empirically estimated evolutionary event-relations containing pairs of orthologous, paralogous or xenologous genes.
Marc Hellmuth
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Attribute Selection Based on Constraint Gain and Depth Optimal for a Decision Tree

Entropy, 2019
Uncertainty evaluation based on statistical probabilistic information entropy is a commonly used mechanism for a heuristic method construction of decision tree learning.
Huaining Sun, Xuegang Hu, Yuhong Zhang
doaj   +1 more source

GR@PPA 2.7 event generator for $pp$/$p\bar{p}$ collisions

, 2006
The GR@PPA event generator has been updated to version 2.7. This distribution provides event generators for $V$ ($W$ or $Z$) + jets ($\leq$ 4 jets), $VV$ + jets ($\leq$ 2 jets) and QCD multi-jet ($\leq$ 4 jets) production processes at $pp$ and $p\bar{p}$
Abe, Belanger, Boos, Boos, Cabbibo, Corcella, Eidelman, Fujimoto, Fujimoto, Giele, Gleisberg, K. Kato, Kawabata, Kobayashi, Krauss, Kurihara, Lai, Maltoni, Mangano, Munehisa, Papadopoulos, Plothow-Besch, S. Odaka, S. Tsuno, Sato, Schälicke, Sjöstrand, T. Kaneko, Tanaka, Tanaka, Tsuno, Y. Kurihara, Yuasa   +32 more
core   +1 more source

Predicting Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex Using a Fusion Model Integrating Lesion Network Mapping and Machine Learning

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu, Qi Wang, Suhui Kuang, Dezhi Cao, Ping Ding, Shaohui Zhang, Haihua Wei, Zhirong Wei, Jinshan Xu, Xinyu Huang, Bing Liu, Shuli Liang   +11 more
wiley   +1 more source

Characterization of Clinical Phenotype to Glial Fibrillary Acidic Protein Concentrations in Alexander Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the concentration of glial fibrillary acidic protein (GFAP) in cerebrospinal fluid (CSF) and plasma in Alexander disease (AxD) and whether GFAP levels are predictive of disease phenotypes. Methods CSF and plasma were collected (longitudinally when available) from AxD participants and non‐AxD controls.
Amy T. Waldman, Asako Takanohashi, Joshua Y. Joung, Geraldine W. Liu, Kaley Arnold, Amy Pizzino, Walter Faig, Sarah Woidill, Sona Narula, Adeline L. Vanderver   +9 more
wiley   +1 more source

Four-fermion production with RACOONWW [PDF]

, 1999
RACOONWW is an event generator for e+e- --> WW --> 4fermions(+gamma) that includes full tree-level predictions for e+e- --> 4f and e+e- --> 4f+gamma as well as O(alpha) corrections to e+e- --> 4f in the so-called double-pole approximation.
A Denner, Altarelli G, Bardin D, Bardin D, Bardin D Yu, Beenakker W, Beenakker W, Beenakker W, D Wackeroth, Denner A, Denner A, Denner A, Denner A, Dittmaier S, Dittmaier S, Fleischer J, Fujimoto J, Jadach S, Jegerlehner F, Jegerlehner F, Jegerlehner F, Kurihara Y, M Roth, Roth M, S Dittmaier   +24 more
core   +2 more sources