Results 1 to 10 of about 169 (168)
Uncovering Dynamic Fault Trees [PDF]
2016 46th Annual IEEE/IFIP International Conference on Dependable Systems and Networks (DSN), 2016 Fault tree analysis is a widespread industry standard for assessing system reliability. Standard (static) fault trees model the failure behaviour of systems in dependence of their component failures. To overcome their limited expressive power, common dependability patterns, such as spare management, functional dependencies, and sequencing are ...
Sebastian Junges +3 more
openaire +1 more source
INCLUDING SYSTEMATIC FAULTS INTO FAULT TREE ANALYSIS [PDF]
IFAC Proceedings Volumes, 2006 : Fault Tree Analysis (FTA) is a technique widely used for fault forecasting of physical systems. Although FTA is considered a well established safety analysis technique, paradoxically classical Fault Trees include only random faults. However, in modem automated systems, undesirable events arise not only from random hardware faults but also from ...
Israel Barragan Santiago +2 more
openaire +1 more source
Parametric Analyses of Attack-Fault Trees [PDF]
2019 19th International Conference on Application of Concurrency to System Design (ACSD), 2019 Risk assessment of cyber-physical systems, such as power plants, connected devices and IT-infrastructures has always been challenging: safety (i. e., absence of unintentional failures) and security (i. e., no disruptions due to attackers) are conditions that must be guaranteed.
André, Étienne +3 more
openaire +6 more sources
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
J. Univers. Comput. Sci., 1999 JUCS - Journal of Universal Computer Science Volume Nr.
openaire +3 more sources
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source