Results 41 to 50 of about 45,933 (222)

PTBP1‐Mediated Alternative Splicing of DNAJB6 Promotes Everolimus Resistance in Clear Cell Renal Cell Carcinoma via EIF4B/PKIB/AKT/mTOR Positive Feedback Loop

Advanced Science, EarlyView.
PTBP1‐mediated alternative splicing drives a pathogenic switch to the DNAJB6b isoform in everolimus‐resistant clear cell renal cell carcinoma. This splicing event programs a positive feedback loop including EIF4B/PKIB/AKT/mTOR, promoting aggressive therapy resistance.
Xiu‐wu Pan, Hong‐feng Zheng, Mu‐chen Li, Jia‐lin Zhou, Hang‐biao Zhang, Dong‐hao Lyu, Yi‐fan Tang, Tian‐yue Yang, Yi‐fan Liu, Zi‐chang Liu, Wen‐jie Ma, Yuan‐bo Zong, Jian‐gui Liu, Zi‐xuan Gong, Hao Zhang, Ke‐qin Dong, Wang Zhou, Jian‐qin Ye, Xin‐gang Cui   +18 more
wiley   +1 more source

CAQ Corner: Immune‐mediated complications

, 2022
Liver Transplantation, EarlyView.
Mary Thomson, John R. Lake
wiley   +1 more source

Everolimus in the Treatment of Metastatic Breast Cancer

, 2015
The discovery of the mammalian target of rapamycin (mTOR) molecular pathway has brought insight into its vital role in breast cancer pathogenesis. Several clinical trials have shown that the mTOR inhibitor everolimus could improve patient outcomes in ...
Diaa Osman, Melanie E. Royce
core   +1 more source

Everolimus initiation and early calcineurin inhibitor withdrawal in heart transplant recipients: a randomized trial. [PDF]

, 2014
In a randomized, open-label trial, everolimus was compared to cyclosporine in 115 de novo heart transplant recipients. Patients were assigned within 5 days posttransplant to low-exposure everolimus (3–6 ng/mL) with reduced-exposure cyclosporine (n = 56),
Andersson, B., Gullestad, L, Jansson, K, Andersson, B, Sigurdardottir, Vilborg, Gude, E.,, Sigurdardottir, V., Eiskjaer, H.,, Dellgren, G., Andersson, B.,, Solbu, D., Gude, E, Dellgren, G.,, Solbu, D, Jansson, Kjell,, Andreassen, A. K., Arora, S.,, Jansson, K., Arora, S, Sigurdardottir, V.,, Rådegran, Göran,, Gustafsson, F., Gullestad, L., Eiskjaer, H, Solbu, D.,, Eiskjaer, H., Radegran, G, Rådegran, Göran, Arora, S., Andreassen, A.K.,, Rdegran, G.,, Gullestad, L.,, Gustafsson, F, Gude, E., Gustafsson, F.,, Lund University., Dellgren, G, Andreassen, A K   +37 more
core   +1 more source

K‐Ras mutation and amplification status is predictive of resistance and high basal pAKT is predictive of sensitivity to everolimus in biliary tract cancer cell lines

Molecular Oncology, 2017
Advanced biliary tract cancer (BTC) has a poor prognosis and limited treatment options. The PI3K/Akt/mTOR signalling pathway is hyperactivated in a subset of BTCs, and clinical activity of the mTOR inhibitor everolimus has been observed in some patients ...
Yvonne Yeung, David K. Lau, Fiona Chionh, Hoanh Tran, Janson W. T. Tse, Andrew J. Weickhardt, Mehrdad Nikfarjam, Andrew M. Scott, Niall C. Tebbutt, John M. Mariadason   +9 more
doaj   +1 more source

Real‐Time Monitoring of Mass and Mechanical Properties in Single Cells and Multicellular Spheroids

Advanced Science, EarlyView.
This study introduces photothermally actuated microcantilevers combined with optical microscopy to simultaneously measure morphology, mass, and mechanical properties of cellular systems in real‐time. The findings link cytoplasm‐dominated mechanical energy dissipation to the Q‐factor as a novel biophysical parameter.
Ilaria Incaviglia, Giulia E. M. Ammirati, Sophie Herzog, Tommy Krug, Nico Strohmeyer, Miguel Camacho Rufino, Matthias P. Lutolf, David A. Weitz, Daniel J. Müller   +8 more
wiley   +1 more source

Silk Fibroin for Cardiovascular Medical Devices: Review of Material Properties, Applications, and Clinical Potential

Advanced NanoBiomed Research, EarlyView.
Silk fibroin is an attractive natural biomaterial that can be engineered into diverse cardiovascular constructs, including vascular grafts, cardiac patches, heart valves, and stent coatings. Its tunable biological and mechanical properties have driven substantial preclinical progress; however, widespread clinical translation in cardiovascular ...
Mahsa Haghighattalab, Matt Govendir, Kristina Andelovic, Zachary Och, Fatemeh Karimi, Munira Xaymardan, Tomasz Jungst, Jelena Rnjak‐Kovacina, Nona Farbehi   +8 more
wiley   +1 more source

Two cases of eczematous eruptions caused by everolimus

Journal of Cutaneous Immunology and Allergy, 2019
Objective Everolimus, an inhibitor of the mammalian target of rapamycin, has been used in the treatment of several types of tumor. Erythematous maculopapular and acneiform rashes are the major dermatological adverse events associated with everolimus ...
Minako Habu, Mikiko Tohyama, Koji Sayama
doaj   +1 more source

Five‐Year Clinical Outcomes of Biodegradable Versus Durable Polymer Drug‐Eluting Stents: A Propensity Score‐Matched Analysis of 4394 Patients

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Biodegradable‐polymer (BP) drug‐eluting stents (DES) were developed to mitigate potential late adverse events related to persistent durable polymers in durable‐polymer (DP) DES; however, contemporary long‐term real‐world comparative data remain limited. Aims We aimed to compare the 5‐year clinical outcomes of contemporary BP‐DES and
Yangyoun Lee, Hong‐Seok Lim, Kyoung‐Woo Seo, Hyoung‐Mo Yang, So‐Yeon Choi, Seung‐Jea Tahk, Myeong‐Ho Yoon   +6 more
wiley   +1 more source

Effect of everolimus introduction on cardiac allograft vasculopathy--results of a randomized, multicenter trial. [PDF]

, 2011
BACKGROUND Everolimus reduces the progression of cardiac allograft vasculopathy (CAV) in de novo heart transplant (HTx) recipients, but the influence on established CAV is unknown.
Wennerblom, Bertil, Thor Ueland, Sigurdardottir, Vilborg, Simonsen, Svein, Saunamaki, Kari, Bötker, Hans E, Arora, Satish, Dag Solbu, Eiskjär, Hans, Ueland, Thor, Bøtker, Hans E, Simonsen, Svein,, Gude, Einar,, Bertil Wennerblom, Mortensen, Svend-Aage,, E. Botker, Hans,, Bjørn Bendz, Bendz, Bjorn,, Pål Aukrust, Solbu, Dag,, Gullestad, Lars,, Lund University., Hans E. Bøtker, Aukrust, Pal,, Gude, Einar, Bjorn Ekmehag, Lars Gullestad, Kari Saunamaki, Hans Eiskjær, Gullestad, Lars, Ekmehag, Bjorn,, Eiskjaer, Hans,, Svein Simonsen, Solbu, Dag, Bendz, Bjørn, Wennerblom, Bertil,, Bendz, Björn, Ekmehag, Bjorn, Jansson, Kjell,, Sigurdadottir, Vilborg, Kjell Jansson, Jansson, Kjell, Mortensen, Svend-Aage, Svend-Aage Mortensen, Ueland, Thor,, Satish Arora, Eiskjær, Hans, Arora, Satish,, Saunamaki, Kari,, Vilborg Sigurdadottir, Aukrust, Pål, Sigurdadottir, Vilborg,, Einar Gude   +52 more
core   +1 more source