Results 81 to 90 of about 45,933 (222)

Comparison of the everolimus concentrations measured in whole blood with everolimus QMS or sirolimus CMIA

, 2018
Few years ago, it was proposed that everolimus blood levels could be determined with the commercially available sirolimus chemiluminescence magnetic microparticle immunoassay (CMIA).
Guida, Bruna, Mosca, Teresa, Cataldi, Mauro, Mauro Cataldi, Giovanni Tarantino, Capone, Domenico, Bruna Guida, Teresa Mosca, Tarantino, Giovanni, Domenico Capone   +9 more
core   +1 more source

Everolimus induces Met inactivation by disrupting the FKBP12/Met complex [PDF]

, 2016
Inhibition of the mechanistic target of rapamycin (mTOR) is a promising treatment strategy for several cancer types. Rapamycin derivatives such as everolimus are allosteric mTOR inhibitors acting through interaction with the intracellular immunophilin ...
FORMISANO, LUIGI, RAIMONDO, LUCIA, di Renzo, Maria Flavia, SERVETTO, ALBERTO, D'AMATO, VALENTINA, COSCONATI, SANDRO, BIANCO, ROBERTO, VENEZIANI, BIANCA MARIA, ROSA, ROBERTA, Napolitano, Filomena, DE MAIO, ANA PAULA, MARCIANO, ROBERTA, Ciciola, Paola, Clara Orsini, Roberta, BRUNO, AGOSTINO, Orsini, Roberta Clara, RANDAZZO, ANTONIO, DE PLACIDO, SABINO, Cascetta, Priscilla, DI MAURO, CONCETTA, MONTUORI, NUNZIA   +20 more
core   +1 more source

Assessing the neuroendocrine and psychological effects of acute everolimus administration in healthy male participants

Brain, Behavior, & Immunity - Health
Previous experimental studies have shown that immunosuppressive mechanistic target of rapamycin inhibitors can induce neuropsychological changes, such as anxiety and depression, in healthy rodents.
Lucie Jacquet, Anna Lena Friedel, Elisa Orth, Nathalie Reiser, Tina Hörbelt-Grünheidt, Sophie Wiczoreck, Oliver Witzke, Manfred Schedlowski, Marie Jakobs   +8 more
doaj   +1 more source

Dynamic tumor modeling of the dose–response relationship for everolimus in metastatic renal cell carcinoma using data from the phase 3 RECORD-1 trial

BMC Cancer, 2012
Background The phase 3 RECORD-1 trial (NCT00410124) established the efficacy and safety of everolimus in patients with metastatic renal cell carcinoma (mRCC) who progress on sunitinib or sorafenib.
Stein Andrew, Wang Wenping, Carter Alison A, Chiparus Ovidiu, Hollaender Norbert, Kim Hyewon, Motzer Robert J, Sarr Celine   +7 more
doaj   +1 more source

Phenotype‐guided etiologic workup in a prospective cohort of 144 adults with developmental and epileptic encephalopathy

Epilepsia Open, EarlyView.
Abstract Objectives Adults with developmental and epileptic encephalopathies (DEEs) often enter adult neurology care without etiologic clarification because of incomplete transition from pediatric services, outdated investigations, and attenuation of childhood electro‐clinical features over time.
Giuseppe d’Orsi, Umberto Costantino, Maria Teresa Di Claudio, Carmela Pia Ferro, Pietro Palumbo, Mario Benvenuto, Massimiliano Copetti, Leonardo D'Agruma, Massimo Carella, Marco Castori, Orazio Palumbo   +10 more
wiley   +1 more source

The role of everolimus in liver transplantation

, 2014
Rainer Ganschow,1 Jörg-Matthias Pollok,2 Martin Jankofsky,3 Guido Junge4 1Department of Pediatrics, 2Department of General, Visceral, Thoracic, and Vascular Surgery, 3Department of Pediatrics, University of Bonn, Bonn, Germany; 4Integrated Hospital ...
Pollok JM, Ganschow R, Junge G, Jankofsky M   +3 more
core  

Everolimus augments the effects of sorafenib in a syngeneic orthotopic model of hepatocellular carcinoma [PDF]

, 2011
Sorafenib targets the Raf/mitogen-activated protein kinase, VEGF, and platelet-derived growth factor pathways and prolongs survival patients in advanced hepatocellular carcinoma (HCC).
McSheehy, Paul M., St-Pierre, Marie V, Ruslan Hlushchuk, Jean-François Dufour, Piguet, Anne-Christine, McSheehy, Paul M. J., Valentin Djonov, McSheehy, Paul M J, Dufour, Jean-François, Vesna Radojevic, St-Pierre, Marie V., Bettina Saar, Djonov, Valentin, Marie V. St-Pierre, Luigi Terracciano, Terracciano, Luigi, Hlushchuk, Ruslan, Maresa Afthinos, Radojevic, Vesna, Afthinos, Maresa, Paul M.J. McSheehy, Saar, Bettina, Anne-Christine Piguet   +22 more
core   +1 more source

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

Clinical Translation of Patient‐Derived Organoids: Perspectives for Personalized Therapy in Cancer

International Journal of Cancer, EarlyView.
ABSTRACT Patient‐derived organoids (PDO) are accelerating precision medicine. These biological platforms allow for the autologous in vitro expansion of material from cancer patients in a considerably short period of time. These three‐dimensional models can faithfully recapitulate aspects of tissue heterogeneity, architecture, and relevant cellular ...
Haiyan Yue, Daniele Carchidi, Philipp Schmucker, Roland Seiler, Bernhard Kiss, Catarina Macedo‐Silva, Marianna Kruithof‐de Julio   +6 more
wiley   +1 more source

Everolimus with Reduced Calcineurin Inhibitor Exposure in Renal Transplantation [PDF]

, 2018
Background Everolimus permits reduced calcineurin inhibitor (CNI) exposure, but the efficacy and safety outcomes of this treatment after kidney transplant require confirmation.
Berger, Stefan P, Bernhardt, Peter, Pascual J., Stefan P. Berger, Marti A., Shamkant Mulgaonkar, Legendre C., Carmellini, M., Qazi Y., Rigotti, Paolo, AnaMaria Marti, Watarai, Yoshihiko, Claudia Sommerer, Sommerer, Claudia, Srinivas, Titte R, Rainer Oberbauer, Peter Bernhardt, Tedesco H., Yoshihiko Watarai, Vincenti, Flavio, Todeschini Paola, Oppenheimer, Federico, TRANSFORM Investigators, Steven Chadban, Helio Tedesco, Srinivas, Titte R., Christophe Legendre, null null, Tedesco, Helio, Yasir Qazi, Chadban, Steven, Julio Pascual, Oberbauer, Rainer, Bernhardt P., Berger, Stefan P., Titte R. Srinivas, Oberbauer R., Citterio F., Flavio Vincenti, TRANSFORM, Investigators, Sommerer C., Oppenheimer F., Srinivas T. R., Mitchell Henry, Mulgaonkar S., Chadban S., Franco Citterio, Witzke, Oliver, Watarai Y., Qazi, Yasir, Berger S. P., Luo W. -L., Marti, AnaMaria, Mulgaonkar, Shamkant, Vincenti F., Legendre, Christophe, Federico Oppenheimer, Oliver Witzke, Pascual, Julio, Luo, Wen-Lin, Henry M., Citterio, Franco, Henry, Mitchell, Wen-Lin Luo, Witzke O.   +64 more
core   +2 more sources