Results 151 to 160 of about 6,549,758 (385)

Reconstructing data : evidence-Based Medicine and Evidence-Based Public Health in context [PDF]

, 2006
The emergence of Evidence-Based Medicine (EBM) as the gold-standard practice in biomedicine and public health practices represents a significant epistemological turn in modern medicine.
Davidovitch, Nadav
core   +6 more sources

The Need for Evidence-Based Medicine [PDF]

, 1995
David L. Sackett, William Rosenberg
openalex   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Evidence-based medicine [PDF]

, 1996
Simon Gilbody
openalex   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Salmonella enterica mediated epigenetic promotion of fibrosis is a novel factor in benign prostatic hyperplasia

Military Medical Research
Background Fibrosis constitutes a significant pathophysiological mechanism in the clinical progression of benign prostatic hyperplasia (BPH) and represents a contributing factor to the ineffectiveness of prevailing pharmacological treatments.
Cong Zhu, Lu-Yao Li, Ming-Hui Shi, Cheng Fang, Lu Yang, Ting Li, Fei Li, Shi-Song Yang, Tian-Kun Wang, Dao-Jing Ming, Tong Deng, Hao-Yue Sun, Wen-Ting Li, Jia Zhang, Yu-Sen Zhang, Zhi-Yuan Jian, Chang-Jiang Qin, Shuang-Ying Wang, Xian-Tao Zeng   +18 more
doaj   +1 more source

QiMing granules for diabetic retinopathy: a systematic review and meta-analysis of randomized controlled trials

Frontiers in Pharmacology
ObjectiveThis study aimed to assess the efficacy and safety of QiMing granules (QM) in the treatment of patients with diabetic retinopathy (DR).MethodsWe systematically searched multiple databases, including Pubmed, Embase, Web of Science, Cochrane ...
Yazi Zhang, Menglong Shi, Dehui Peng, Weijie Chen, Yucong Ma, Wenting Song, Yuetong Wang, Haiyin Hu, Zhaochen Ji, Zhaochen Ji, Fengwen Yang   +10 more
doaj   +1 more source

Many questions cannot be answered by evidence based medicine [PDF]

, 1995
O. Dearlove, A. Sharples, Kelly K. O’Brien, Colin Dunkley   +3 more
openalex   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Evidence-based medicine and the journal club: a cross-sectional survey of participants' views [PDF]

, 1997
James Warner, Micháel J. King
openalex   +1 more source