Results 151 to 160 of about 6,906,802 (378)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Salmonella enterica mediated epigenetic promotion of fibrosis is a novel factor in benign prostatic hyperplasia

Military Medical Research
Background Fibrosis constitutes a significant pathophysiological mechanism in the clinical progression of benign prostatic hyperplasia (BPH) and represents a contributing factor to the ineffectiveness of prevailing pharmacological treatments.
Cong Zhu, Lu-Yao Li, Ming-Hui Shi, Cheng Fang, Lu Yang, Ting Li, Fei Li, Shi-Song Yang, Tian-Kun Wang, Dao-Jing Ming, Tong Deng, Hao-Yue Sun, Wen-Ting Li, Jia Zhang, Yu-Sen Zhang, Zhi-Yuan Jian, Chang-Jiang Qin, Shuang-Ying Wang, Xian-Tao Zeng   +18 more
doaj   +1 more source

Treatment of Patients with COVID-19 and Concomitant Cardiovascular Diseases: Do not Forget About the Principles of Evidence-based Medicine

, 2020
S. Yu. Martsevich
openalex   +2 more sources

Why Technology Provides Compelling Reasons to Apply a Daubert Analysis to the Legal Standard of Care in Medical Malpractice Cases [PDF]

, 2006
Traditionally, courts have applied a customary practice standard in determining the legal standard of care in medical malpractice cases. Recently, a few courts have abandoned this dated standard and instead applied a Daubert analysis to the standard of
Hines, Nichole
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Evidence based medicine meets genomic medicine [PDF]

, 2007
Jim Evans, Muin J. Khoury
openalex   +1 more source

Nootropic drugs for correction of cognitive functions through the focus of evidence-based medicine (literature review)

, 2021
А Гайдабрус, М. С. Потапенко, М. В. Романенко, Гайдабрус Володимирович, Andriy V. Haydabrus, V Karazіn, Mariam Potapenko, Maxim A. Romanenko   +7 more
openalex   +2 more sources

Replacement for the 10 page paper? A pilot project using blogs and wikis for a collaborative EBM assignment in a 3rd year internal medical clerkship [PDF]

, 2009
Objective Pilot a group assignment using blogs and wikis to develop evidence-based medicine skills in third year medical students on an internal medicine clerkship.
Frisby, PhD, Anothny J., Grasberger, MS, Margy, Kaplan, MSLIS, Gary E., Kipnis, MSI, Daniel G, Krasznavolgyi, MLS, Karen, Salt, MD, Jessica, Veloski, MS, J. Jon   +6 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

QiMing granules for diabetic retinopathy: a systematic review and meta-analysis of randomized controlled trials

Frontiers in Pharmacology
ObjectiveThis study aimed to assess the efficacy and safety of QiMing granules (QM) in the treatment of patients with diabetic retinopathy (DR).MethodsWe systematically searched multiple databases, including Pubmed, Embase, Web of Science, Cochrane ...
Yazi Zhang, Menglong Shi, Dehui Peng, Weijie Chen, Yucong Ma, Wenting Song, Yuetong Wang, Haiyin Hu, Zhaochen Ji, Zhaochen Ji, Fengwen Yang   +10 more
doaj   +1 more source