Results 141 to 150 of about 3,238,711 (292)

Insights from Evidence-Based Medicine Method for Building Security Systems Against Terrorist Attacks in Hospitals

, 2023
Guochen Chen, Gaofeng Jin School of Criminology, People’s Public Security University of China, Beijing, People’s Republic of ChinaCorrespondence: Guochen Chen, School of Criminology, People’s Public Security University of China, Beijing, People’s ...
Jin G, Chen G
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IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Chinese Herbal Medicine for Functional Abdominal Pain Syndrome: From Clinical Findings to Basic Understandings

, 2016
Functional abdominal pain syndrome (FAPS) is one of the less common functional gastrointestinal disorders. Conventional therapy has unsatisfactory response to it so people turn to Chinese medicine for help.
Liu, T, Wang, N, Zhong, LD, Zhang, L
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Sensor data on cow activity, rumination, and ear temperature improve prediction of the start of calving in dairy cows

, 2017
Management during calving is important for the health and survival of dairy cows and their calves. Although the expected calving date is known, this information is imprecise and farmers still have to check a cow regularly to identify when it starts ...
Dep Gezondheidszorg Landbouwhuisdieren, Nielen, M., Sub Economie, dFAH AVR, Kamphuis, C., Steeneveld, W., Rutten, C. J., Rutten, C.J., Huijps, K., Hogeveen, H., LS Evidence Based Vet Medicine   +10 more
core   +1 more source

Effectiveness of simulation-based clinical research curriculum for undergraduate medical students - a pre-post intervention study with external control

BMC Medical Education
Background Simulation is widely utilized in medical education. Exploring the effectiveness of high-fidelity simulation of clinical research within medical education may inform its integration into clinical research training curricula, finally cultivating
Qiao Huang, Si-Yu Yan, Jiao Huang, Yi Guo, Xian-Tao Zeng, Ying-Hui Jin   +5 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

ACIP Evidence-Based Recommendations Work Group proposal [PDF]

Presentations February 2018 Day 1Publication date from document properties.EBR-02-Carr-508 ...

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Evidence-Based Medicine: Feminist Criticisms and Implications for Women's Health

, 2022
Evidence-Based Medicine: Feminist Criticisms and Implications for Women's ...
K Tsey (9849185), L Merone (9889610), D Russell (4685143), A Daltry (14584103), Catherine Nagle (13063122)   +4 more
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Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source