Results 121 to 130 of about 3,238,711 (292)

Salmonella enterica mediated epigenetic promotion of fibrosis is a novel factor in benign prostatic hyperplasia

Military Medical Research
Background Fibrosis constitutes a significant pathophysiological mechanism in the clinical progression of benign prostatic hyperplasia (BPH) and represents a contributing factor to the ineffectiveness of prevailing pharmacological treatments.
Cong Zhu, Lu-Yao Li, Ming-Hui Shi, Cheng Fang, Lu Yang, Ting Li, Fei Li, Shi-Song Yang, Tian-Kun Wang, Dao-Jing Ming, Tong Deng, Hao-Yue Sun, Wen-Ting Li, Jia Zhang, Yu-Sen Zhang, Zhi-Yuan Jian, Chang-Jiang Qin, Shuang-Ying Wang, Xian-Tao Zeng   +18 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Chinese Herbal Medicine as Adjunctive Therapy to Chemotherapy for Breast Cancer : A Systematic Review and Meta-Analysis

, 2016
Chinese herbal medicine (CHM) has been increasingly employed during therapy for breast cancer, but its efficacy remains a matter of debate. This systematic review examined randomized controlled trials to provide a critical evaluation of this treatment ...
Nian, Jia-Yun,, Zhang, Xing, Nian, Jia-Yun, Yu, Ming-Wei,, Yang, Guo-Wang,, Yu, Ming-Wei, Zhang, Yi, Zhang, Xing,, Cheng, Pei-Yu,, Guo, Jiao, Sun, Xu, Li, Jin-Ping, Wang, Xiao-Min,, Zhang, Gan-Lin, Zhang, Yi,, Wang, Xiao-Min, Yang, Guo-Wang, Cheng, Pei-Yu, Sun, Xu,, Yang, Lin,, Yin, Yi,, Guo, Jiao,, Yang, Lin, Yin, Yi, Zhang, Gan-Lin,, Li, Jin-Ping,   +25 more
core   +1 more source

Association Between Heart Rate at Diagnosis and Long-Term Recurrence Risk of Pulmonary Embolism in a Historical Cohort Study of Elder Women

Clinical and Applied Thrombosis/Hemostasis
To investigate the association between heart rate (HR) at diagnosis and long-term pulmonary embolism (PE) recurrence among elderly (≥ 50 year-old) female patients after acute PE (APE).
Yuan Li MD, PhD, Fang Li PhD, Meizhi Li MS, Qiong Yi MS, Shangjie Wu MD   +4 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

PICC超声引导下肘上置管的穿刺置管效果及并发症的系统评价

, 2013
Objective 　To systematically evaluate the influence of PICC (peripherally inserted central catheter) ultrasound guidance on success rates and incidences of complications of elbow catheterization.Methods 　The Cochrane Library (Issue 3, 2012), Library of ...
Lu, Zhenqi, Li, Quanlei, Yan, Meiqiong, Zhang, Xiaoju, Lin, Cen   +4 more
core   +1 more source

Epigallocatechin-3-gallate inhibits H2O2-induced apoptosis in Mouse Vascular Smooth Muscle Cells via 67kD Laminin Receptor

Scientific Reports, 2017
Epigallocatechin-3-gallate (EGCG) is one of the major polyphenolic compounds present in green tea extracts and has been used as a potential drug for the treatment of numerous diseases.
Xue Yan, Yanfei Li, Han Yu, Wei Wang, Chunyan Wu, Yang Yang, Yongjia Hu, Xiujuan Shi, Jue Li   +8 more
doaj   +1 more source

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

Fallacies of Evidence-Based Medicine in Cardiovascular Medicine.

, 2019
Evidence-based medicine (EBM) has gained a dominant role as the backbone of modern medical activities since its definition about 20 years ago. It serves the purpose to unify and optimize patient management and minimize scientific bias and fraud.
Nietlispach, Fabian, Meier, Bernhard
core   +1 more source

QiMing granules for diabetic retinopathy: a systematic review and meta-analysis of randomized controlled trials

Frontiers in Pharmacology
ObjectiveThis study aimed to assess the efficacy and safety of QiMing granules (QM) in the treatment of patients with diabetic retinopathy (DR).MethodsWe systematically searched multiple databases, including Pubmed, Embase, Web of Science, Cochrane ...
Yazi Zhang, Menglong Shi, Dehui Peng, Weijie Chen, Yucong Ma, Wenting Song, Yuetong Wang, Haiyin Hu, Zhaochen Ji, Zhaochen Ji, Fengwen Yang   +10 more
doaj   +1 more source