Results 101 to 110 of about 3,238,711 (292)

The Philosophy of Evidence-Based Medicine

, 2011
Evidence-based medicine (EBM) has become a required element of clinical practice, but it is critical for the healthcare community to understand the ongoing controversy surrounding EBM.
Howick, Jeremy, Jeremy Howick, howick,jeremy, Howick, J   +3 more
core   +1 more source

Phase-engineered MoS2 nanosheets/probiotic vesicles hydrogel for diabetic wound healing via dynamic ROS modulation

Journal of Nanobiotechnology
Diabetic wound repair remains a huge clinical challenge and drives demand for advanced therapies. Most novel nanomaterial-based dressings exploit elevated reactive oxygen species (ROS) for antibacterial efficacy are short of the intelligent of ROS ...
Yu-Sen Zhang, Shuai Ke, Jia Zhang, Meng Luo, Bing-Hui Li, Xing-Xian Liu, Zhi-Jun Lu, Ruo-Fei Liu, Xian-Tao Zeng, Ling-Ling Zhang   +9 more
doaj   +1 more source

Ethics and evidence based medicine

BMJ, 1998
Evidence based medicine is founded upon an ideal—that decisions about the care of individual patients should involve the “conscientious, explicit and judicious use of current best evidence.”1 Several publications are dedicated to evidence based medicine, and, at an international level, the Cochrane Collaboration has been formed to gather, analyse, and ...
Kerridge, I, Lowe, M, Henry, D
openaire   +4 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Narrative based medicine: narrative based medicine in an evidence based world

, 1999
Summary points: Even "evidence based" clinicians uphold the importance of clinical expertise and judgment. Clinical method is an interpretive act which draws on narrative skills to integrate the overlapping stories told by patients, clinicians, and test ...
Greenhalgh, T., Greenhalgh, T, T. Greenhalgh, Greenhalgh, Trisha   +3 more
core   +1 more source

A Randomized, Sham-Controlled Trial on the Efficacy and Safety of Electroacupuncture for Lumbar Disc Herniation with Radiculopathy: Rationale and Study Protocol

Journal of Pain Research
Yuwei Yang,1,* Liting Liu,1,* Lixia Yuan,1 Xiaoya Liu,1 Haoying Ding,2 Xu Zhou,3 Qianan Cao4 1Graduate School, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, 330004, People’s Republic of China; 2The First Department of ...
Yang Y, Liu L, Yuan L, Liu X, Ding H, Zhou X, Cao Q   +6 more
doaj  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Valuing Evidence: Bias and the Evidence Hierarchy of Evidence-Based Medicine

, 2009
No abstract ...
Borgerson, Kirstin
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source