Results 151 to 160 of about 32,744,920 (289)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

‘You only care when it hurts’ - men’s engagement with their health: a qualitative interview study in Lower Austria

BMC Public Health
Background Compared with women, men have a lower life expectancy, engage more frequently in risky health behaviours, underuse preventive healthcare services, and are less likely to attend routine health checks or seek mental health support.
Ursula Griebler, Julia Daxenbichler, Isabel Moser, Nina Mitterbauer, Alexander Pell, Denise Hebesberger, Christina Koscher-Kien   +6 more
doaj   +1 more source

QiMing granules for diabetic retinopathy: a systematic review and meta-analysis of randomized controlled trials

Frontiers in Pharmacology
ObjectiveThis study aimed to assess the efficacy and safety of QiMing granules (QM) in the treatment of patients with diabetic retinopathy (DR).MethodsWe systematically searched multiple databases, including Pubmed, Embase, Web of Science, Cochrane ...
Yazi Zhang, Menglong Shi, Dehui Peng, Weijie Chen, Yucong Ma, Wenting Song, Yuetong Wang, Haiyin Hu, Zhaochen Ji, Zhaochen Ji, Fengwen Yang   +10 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Safety of anti-infective agents use during pregnancy on offspring: protocol for an umbrella review incorporating a novel three-stage data extraction strategy

Systematic Reviews
Background Anti-infective agents are widely used during pregnancy to prevent, treat, and mitigate the transmission of infections, and their utilisation has significantly increased over the past decade.
Wenling Wang, Long Ge, Yiquan Xiong, Jingwen Chen, Chen Chen, Yan Ren, Lehana Thabane, Xin Sun, Jing Tan   +8 more
doaj   +1 more source

"Evidence-Debased Medicine" and the Integrity of the Medical Profession

, 2011
Patients trust physicians to prescribe based on their fiduciary duty to act in the best interests of their patients, and physicians prescribe based on confidence in research data and clinical guidelines.
Elliott, Richard L
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Missing men – why health promotion leaves them behind and how to bring them on board: results of a rapid qualitative evidence synthesis

BMC Public Health
Background Men show a higher mortality than women, especially at a young age (between 15 and 39 years). They are more likely to engage in unhealthy behaviours and tend not to implement preventative efforts or to seek help. While (mental) health promotion
Nina Mitterbauer, Denise V. Hebesberger, Julia Daxenbichler, Karolina Seidl, Irma Klerings, Christina Koscher-Kien, Ursula Griebler   +6 more
doaj   +1 more source