Results 161 to 170 of about 6,549,758 (385)

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Treating avulsion fractures of the base of the fifth metatarsal. [PDF]

, 1999
Barbara J. Martin
openalex   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Reply to “Ten Simple Rules for Getting Published” [PDF]

, 2007
Anon, Eric Grosch, Evidence-Based Medicine Working Group   +2 more
core   +3 more sources

Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Steroids in De Quervain's tenosynovitis. [PDF]

, 1998
Angela Jones
openalex   +1 more source

Evidence based medicine: what it is and what it isn't

British medical journal, 1996
D. Sackett, W. Rosenberg, James Douglas Allan Gray, Haynes Rb, W. Richardson   +4 more
semanticscholar   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Association Between Heart Rate at Diagnosis and Long-Term Recurrence Risk of Pulmonary Embolism in a Historical Cohort Study of Elder Women

Clinical and Applied Thrombosis/Hemostasis
To investigate the association between heart rate (HR) at diagnosis and long-term pulmonary embolism (PE) recurrence among elderly (≥ 50 year-old) female patients after acute PE (APE).
Yuan Li MD, PhD, Fang Li PhD, Meizhi Li MS, Qiong Yi MS, Shangjie Wu MD   +4 more
doaj   +1 more source

Corrigendum to “Antidiabetic Properties, Bioactive Constituents, and Other Therapeutic Effects of Scoparia dulcis” [PDF]

, 2017
Evidence-Based Complementary and Alternative Medicine
core   +2 more sources

The Requirements for Ontologies in Medical Data Integration: A Case Study

, 2007
Evidence-based medicine is critically dependent on three sources of information: a medical knowledge base, the patients medical record and knowledge of available resources, including where appropriate, clinical protocols.
Anjum, Ashiq, Bloodsworth, Peter, Branson, Andrew, Hauer, Tamas, McClatchey, Richard, Munir, Kamran, Rogulin, Dmitry, Shamdasani, Jetendr   +7 more
core   +1 more source