Results 51 to 60 of about 6,749,585 (382)

A systematic review of high quality randomized controlled trials investigating motor skill programmes for children with developmental coordination disorder. [PDF]

, 2017
To identify effective motor training interventions for children with developmental coordination disorder from research graded as high quality (using objective criteria) for the purpose of informing evidence-based clinical practice.We followed the ...
Bruininks R, Centre for Evidence-Based Physiotherapy, Centre for Reviews and Dissemination, Chia CLC, Coe R, Elizabeth Andrews, Henderson S, Henderson SE, Hillier S, Liam JB Hill, Mark Mon-Williams, Nick Preston, Oxford Centre for Evidence-based Medicine Levels of Evidence Working Group, Polatajko H, Sara M Ahern, Sara Magallón, Silkwood-Sherer D   +16 more
core   +2 more sources

Efficacy and safety of thiazolidinediones in diabetes patients with renal impairment: a systematic review and meta-analysis

Scientific Reports, 2017
We conducted a systematic review and meta-analysis to evaluate the efficacy and safety of TZDs in treatment of diabetes mellitus patients with renal impairment. We searched PubMed, EMBASE and Cochrane Central Register of Controlled Trials.
Wen Wang, Xu Zhou, Joey S. W. Kwong, Ling Li, Youping Li, Xin Sun   +5 more
doaj   +1 more source

Prompt engineering in consistency and reliability with the evidence-based guideline for LLMs

npj Digit. Medicine
The use of large language models (LLMs) in clinical medicine is currently thriving. Effectively transferring LLMs’ pertinent theoretical knowledge from computer science to their application in clinical medicine is crucial.
Li Wang, Xi Chen, Xiangwen Deng, Hao Wen, M. You, Weizhi Liu, Qi Li, Jian Li   +7 more
semanticscholar   +1 more source

Characteristics and recovery methods of studies falsely excluded during literature screening—a systematic review

Systematic Reviews, 2022
Background Due to the growing need to provide evidence syntheses under time constraints, researchers have begun focusing on the exploration of rapid review methods, which often employ single-reviewer literature screening.
Lisa Affengruber, Andreea Dobrescu, Emma Persad, Irma Klerings, Gernot Wagner, Isolde Sommer, Gerald Gartlehner   +6 more
doaj   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

The effect of e-cigarettes on smoking cessation and cigarette smoking initiation: An evidence-based rapid review and meta-analysis

Tobacco Induced Diseases, 2021
Introduction The contribution made by e-cigarettes to smoking cessation continues to be controversial. Reports suggest that teenagers are becoming increasingly addicted to e-cigarettes and that e-cigarette use in adolescents is associated with subsequent
Ying-Ying Zhang, Fan-Long Bu, Fei Dong, Jian-Hua Wang, Si-Jia Zhu, Xiao-Wen Zhang, Nicola Robinson, Jian-Ping Liu   +7 more
doaj   +1 more source

The Impact of Evidence-Based Medicine on Qualitative Metasynthesis: Benefits to be Harvested and Warnings to be Given

Qualitative Health Research, 2018
Qualitative metasynthesis, developed as an interpretative and inductive methodology, is increasingly influenced by standards from evidence-based medicine, established as a strategy to support policy decisions and guidelines.
K. Malterud
semanticscholar   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Evidence-based policymaking is not like evidence-based medicine, so how far should you go to bridge the divide between evidence and policy?

Health Research Policy and Systems, 2017
There is extensive health and public health literature on the ‘evidence-policy gap’, exploring the frustrating experiences of scientists trying to secure a response to the problems and solutions they raise and identifying the need for better evidence to ...
P. Cairney, K. Oliver
semanticscholar   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source