Results 71 to 80 of about 6,749,585 (382)

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Design and statistical analysis reporting among interrupted time series studies in drug utilization research: a cross-sectional survey

BMC Medical Research Methodology
Introduction Interrupted time series (ITS) design is a commonly used method for evaluating large-scale interventions in clinical practice or public health. However, improperly using this method can lead to biased results.
Yuanjin Zhang, Yan Ren, Yunxiang Huang, Minghong Yao, Yulong Jia, Yuning Wang, Fan Mei, Kang Zou, Jing Tan, Xin Sun   +9 more
doaj   +1 more source

Efficacy and safety of herbal medicine (Lianhuaqingwen) for treating COVID-19: A systematic review and meta-analysis

Integrative Medicine Research, 2021
Background: Lianhuaqingwen (LH) has been proven effective for influenza. However, the promotion of LH for the treatment of patients with COVID-19 remains controversial.
Ming Liu, Ya Gao, Yuan Yuan, Kelu Yang, Shuzhen Shi, Jinhui Tian, Junhua Zhang   +6 more
doaj   +1 more source

Evidence-based medicine and precision medicine: Complementary approaches to clinical decision-making

Precision Clinical Medicine, 2018
Evidence-based medicine is widely promoted for decision-making in health care and is associated with improved patient outcomes. Critics have suggested that evidence-based medicine focuses primarily on groups of patients rather than individuals, but often
Ngai Chow, L. Gallo, J. Busse
semanticscholar   +1 more source

Quality healthcare, evidence-based medicine and translational research [PDF]

, 2011
Advances in medical care ensure that with the passage of time we are increasingly able to effectively tackle diverse medical problems. These advances, however, do come at a cost and the benefits derived need to be assessed on a regular basis.
Vassallo, Josanne
core  

The compass, crow's nest and ship of medicine in the sea of uncertainties [PDF]

, 2009
Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Discipline of Emergency Medicine and Evidence-Based MedicineAssociação Paulista de MedicinaUNIFESP, EPM, Discipline of Emergency Medicine and Evidence-Based ...
Atallah, Álvaro Nagib
core   +2 more sources

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Neutrophil-to-albumin ratio as a predictor of mortality in patients with intracerebral hemorrhage: a multicenter retrospective cohort study

BMC Neurology
Background Intracerebral hemorrhage (ICH) is associated with a poor prognosis. The association between the neutrophil-to-albumin ratio (NAR) with mortality in patients with ICH remains underexplored.
Jun Wan, Sen Zhang, Xiang Yuan, Yuyang Liu, Xin Cheng, Hao Liu, Fengrui Yang, Yinquan Ai, Xiaohong Luo, Yuting Zhong, Shiqiao Liu, Yu Zhang   +11 more
doaj   +1 more source

How are "teaching the teachers" courses in evidence based medicine evaluated? A systematic review [PDF]

, 2010
Background Teaching of evidence-based medicine (EBM) has become widespread in medical education. Teaching the teachers (TTT) courses address the increased teaching demand and the need to improve effectiveness of EBM teaching.
A Coomarasamy, Andrea R Horvath, Anna Kaleta, Ben WJ Mol, Berit Meyerrose, Bernard Burnand, CA Cartwright, Chantal Arditi, DH Naftulin, Elżbieta Gabryś, GD Fenstermacher, Gee Harry, Gemma Barnfield, Gianni Zanrei, I Bates, J Kouhpayehzadeh, Jacek Walczak, JJ Deeks, JL Dorsch, Katja Suter, Katrien Oude Rengerink, Khalid S Khan, Krzysztof Kloc, KS Khan, L Darling-Hammond, L Fritsche, L Hutchinson, M Wilkes, MK Aiyer, ML Green, O Ribeiro, R Kulier, R Yousefi-Nooraie, Regina Kunz, S Thangaratinam, SF Coppus, Shakila Thangaratinam, Susanne Weinbrenner, T Shaneyfelt, Theodoros N Arvanitis   +39 more
core   +9 more sources

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source