Results 91 to 100 of about 6,370,911 (268)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

دور العادة في تأسيس الدليل النقلي عند الجويني

İslam Medeniyeti Araştırmaları Dergisi
في سياق نظام المعرفة عند الإنسان تبرز العادة أو النواميس الحاكمة للكون والإنسان فردًا ومجتمعًا في تأسيس معرفة الإنسان ونظرته للأشياء المحيطة به وتعامله معها، وتكوِّن هذه العادات مع دليل العقل الأساس الذي تستند إليه كل العلوم والتي منها العلوم الدينية ...
Mustafa Dakkak
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Admissibility of evidence before the Inter-American Court of Human Rights

Revista Direito GV
The Inter-American Court of Human Rights performs a wide evidentiary analysis, which tends to be very flexible in its admission of evidence. This paper tries to decipher the extent, applicability, and content of the Court’s admissibility rules, both the ...
Álvaro Paúl
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Evidence and consensus-based German guidelines for the management of analgesia, sedation and delirium in intensive care – short version

GMS German Medical Science, 2010
Targeted monitoring of analgesia, sedation and delirium, as well as their appropriate management in critically ill patients is a standard of care in intensive care medicine. With the undisputed advantages of goal-oriented therapy established, there was a
Kleinschmidt, Stefan, Koppert, Wolfgang, Kessler, Paul, Huth, Ralf, Hartl, Wolfgang, Haase, Ulrike, Garten, Lars, Engelmann, Lothar, Eichler, Ingolf, Eggers, Verena, Dictus, Christine, Dall, Peter, Bürkle, Hartmut, Biniek, Rolf, Bäsell, Katrin, Baron, Ralf, Heymann, Anja, Martin, Jörg, Kretz, Franz-Josef, Laubenthal, Heinz, Marggraf, Guenter, Meiser, Andreas, Neugebauer, Edmund, Neuhaus, Ulrike, Putensen, Christian, Quintel, Michael, Reske, Alexander, Roth, Bernard, Scholz, Jens, Schröder, Stefan, Schreiter, Dierk, Schüttler, Jürgen, Schwarzmann, Gerhard, Stingele, Robert, Tonner, Peter, Tränkle, Philip, Treede, Rolf Detlef, Trupkovic, Tomislav, Tryba, Michael, Wappler, Frank, Waydhas, Christian, Spies, Claudia   +41 more
doaj  

Meta-Epistemological Remarks on Certainty, Truthfulness, and Evidence: Prolegomena to a Possible Theory Explaining Their Interconnections

Analiza i Egzystencja
The paper discusses semantic and pragmatic relations among three concepts and terms: certainty, truth and evidence (obviousness), and provides prolegomena for a possible epistemological theory explaining how these epistemic values are interconnected ...
Jan Hartman
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Evidence or Evident?

, 2006
Il significato epistemologico dell ...
openaire   +1 more source