Results 111 to 120 of about 12,163,693 (291)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
, 2020 Based on the results of our search, ‘dry’ or hydrophobic systems are preferred from a HCW safety perspective. Cook7 recommends that “Actively heated and humidified ‘wet circuits’ may be avoided after tracheal intubation to avoid viral load being present ...
National Health Library and Knowledge Service Evidence Team +3 more
core
Editorial: Insights in orthopaedic surgery: 2021
Frontiers in Surgery, 2023 Jaimo Ahn
doaj +1 more source
INTERNAL CONVICTION OR THE STANDARD OF PROOF?
Правовое государство: теория и практикаThe article, devoted in general to evidence in criminal proceedings, focuses on the problem of standards of proof and their role in ensuring the fairness of court decisions.
MASHOVETS Asiia Okeanovna
doaj +1 more source
Introduction: How evident is the evidence?
Fertility and sterility, 2020 Randomized controlled trials (RCTs) and meta-analyses are the pinnacle of evidence-based medicine, enabling identification of the best available diagnostic, interventional, and therapeutic options. These tools help clinicians and policy makers to set clinical guidelines, but they also represent a double-edged sword: The meaningfulness of RCTs and meta ...
openaire +3 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Evidence summary: COVID-19 - physiotherapy rehabilitation [v2.0]
, 2020 A team of expert researchers and clinicians within the intensive care and acute cardiorespiratory fields have collaborated to produce: Physiotherapy management for COVID-19 in the acute hospital setting: recommendations to guide clinical practice1. These
National Health Library and Knowledge Service Evidence Team
core
Visum et Repertum as criminal evidence within the Indonesian criminal justice system
International Review of Social Sciences ResearchThis research discusses the use of Visum et Repertum (VeR), an expert testimony, as evidence in criminal justice system in Indonesia. The main issue identified in this research is the legal vacuum regarding the use of VeR before the investigation, which ...
Tohom Hasiholan +3 more
doaj +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source