Results 221 to 230 of about 5,008,997 (292)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

The Role of Big Data in Developing Innovative Predictive Learning Models for Neglected Tropical Diseases within the New Generation of the Evidence-Based Medicine Pyramid. [PDF]

Infez Med
Vidal-Durango JV, Galván-Barrios J, Reyes-Duque JD, Lozada-Martinez ID.   +3 more
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Adoption of evidence-based medicine: A comparative study of hospital and community pharmacists in Saudi Arabia. [PDF]

PLoS One
Alzahrani F, Almutairi N, Aloufi A, Kattan A, Hakeem A, Alharbi M, Alarawi N, Fadil HA, Habeeb E.   +8 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

The state of mechanistic research in the evidence-based medicine era: A sandwalk between triangulation and hierarchies. [PDF]

Exp Physiol
Berg RMG, Durrer CG, Friis JKBO, Ried-Larsen M.   +3 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Investigating the knowledge attitude and practice of evidence based medicine education in Sudanese medical students: a cross sectional study. [PDF]

BMC Med Educ
Amin MHJ, Awad MH, Mohamed Ginawi ES, Mohammed ASK, Noureldaiem Ibrahim EHE, Yassen OYM, Elomeiri LESMA, Hakim Hussain AHMA, Eltahir TA, Mohmmed FSAA, Wedatalla RAE, Awad KH, Mahgoub RKE, Karar AMA, Saeed AYM, Mohamed AEA, Mohamed Ginawi RS, Sidar FMK, Saifalsorori RRA, Osman OIA, Nouri MAI, Mohamed MAA, Ibrahim NBM, Mohamed MMM, Mohamed AEAB, MohamedAhmed FMA, Hassan MRM, Mohamed SAA, Bashar Hadi HE, Gandour HMNG, Ahmed NAF, Ahmed NME, Osman MMAA, Elhadi SEI.   +33 more
europepmc   +1 more source

Librarians in Action: The COVID-19 Evidence Based Medicine Rapid Response Team [PDF]

, 2020
Amy, Blevins E., Hinrichs, Rachel J.
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source