Results 71 to 80 of about 172,980,963 (238)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Commission on Evidence-Based Policymaking

, 2017
Website for the Commission on Evidence-Based Policymaking (CEP), which was established to create a strategy for increasing access to data about government programs while protecting confidentiality. It includes hearings, meeting minutes, and news as well
United States. Commission on Evidence-Based Policymaking.
core  

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Evidence 2010-2011

, 2010
xxxiv+202hlm ...
EVIDENCE
core  

Rapid Evidence Review: COVID-19 and elderly (over 65)

, 2020
Since COVID‐19 seems to have a similar pathogenic potential as SARS‐CoV and MERS‐CoV,6 older adults are likely to be at increased risk of severe infections, cascade of complications, disability and death, as observed with influenza and respiratory ...
National Health Library and Knowledge Service Evidence Team
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Total hip replacement and surface replacement for the treatment of pain and disability resulting from end-stage arthritis of the hip (review of technology appraisal guidance 2 and 44): systematic review and economic evaluation

Health Technology Assessment, 2015
Background: Total hip replacement (THR) involves the replacement of a damaged hip joint with an artificial hip prosthesis. Resurfacing arthroplasty (RS) involves replacement of the joint surface of the femoral head with a metal surface covering ...
Aileen Clarke, Ruth Pulikottil-Jacob, Amy Grove, Karoline Freeman, Hema Mistry, Alexander Tsertsvadze, Martin Connock, Rachel Court, Ngianga-Bakwin Kandala, Matthew Costa, Gaurav Suri, David Metcalfe, Michael Crowther, Sarah Morrow, Samantha Johnson, Paul Sutcliffe   +15 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Burden of metabolic dysfunction-associated steatohepatitis, with and without metabolic syndrome, obesity, or diabetes

BMC Gastroenterology
Background Metabolic dysfunction-associated steatohepatitis (MASH) is commonly comorbid with metabolic syndrome; however, MASH can occur in the absence of metabolic syndrome.
Elliot B. Tapper, Taylor Ryan, Dave Lewandowski, Jessamine P. Winer-Jones, Machaon Bonafede, Yestle Kim   +5 more
doaj   +1 more source

The value of uncertainty: the Zika and Microcefalia link

Journal of Evidence-Based Healthcare, 2019
Scientific paradigm violations are common in the medical literature. This article aims to describe the principles that should guide scientific thinking, such as the philosophy of skepticism, the consideration of multiple hypothesis, epidemiological ...
Denise Silva Matias, Luis Cláudio Lemos Correia, Daniel Oliveira Medina da Silva, Larrie Rabelo Laporte, Camila Verônica Souza Freire, Gabriel de Araújo Grisi, Thiago Masashi Taniguchi, Mariana Correia Moreira Cruz   +7 more
doaj   +1 more source