Results 81 to 90 of about 172,980,963 (238)

Sustainability of knowledge translation interventions: the evidence lacks evidence. [PDF]

BMC Med, 2023
Descatha A, Fadel M.
europepmc   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

A Randomized, Sham-Controlled Trial on the Efficacy and Safety of Electroacupuncture for Lumbar Disc Herniation with Radiculopathy: Rationale and Study Protocol

Journal of Pain Research
Yuwei Yang,1,* Liting Liu,1,* Lixia Yuan,1 Xiaoya Liu,1 Haoying Ding,2 Xu Zhou,3 Qianan Cao4 1Graduate School, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, 330004, People’s Republic of China; 2The First Department of ...
Yang Y, Liu L, Yuan L, Liu X, Ding H, Zhou X, Cao Q   +6 more
doaj  

What is evidence as evidence is used? A case of dualism? [PDF]

Soc Theory Health, 2022
Fletcher AN.
europepmc   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Living evidence profile #6.11: What is the best-available evidence related to the monkeypox outbreak?

, 2022
An overview of the best available research evidence from around the world (i.e., evidence syntheses) and local research evidence (i.e., single studies) and, if applicable, a scan of experiences from other countries and from Canadian provinces and ...
Alam, S, Evans, C, DeMaio, P, Sharma, K, El-Kadi, A, Loeb, M, Bain, T, Velez, CM, Wang, A, Sivanesanathan, T, Yu, T, Wilson, MG, Lavis, JN, Soueidan, S   +13 more
core  

Comparative effectiveness of beta-interferons and glatiramer acetate for relapsing-remitting multiple sclerosis: systematic review and network meta-analysis of trials including recommended dosages

BMC Neurology, 2018
Background We systematically reviewed the comparative effectiveness of injectable beta-interferons (IFN-β) and glatiramer acetate (GA) on annualised relapse rate (ARR), progression and discontinuation due to adverse events (AEs) in RRMS, using evidence ...
G. J. Melendez-Torres, Xavier Armoiry, Rachel Court, Jacoby Patterson, Alan Kan, Peter Auguste, Jason Madan, Carl Counsell, Olga Ciccarelli, Aileen Clarke   +9 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Pulmonary Function Decline in Alpha-1 Antitrypsin Deficiency: A Systematic Review and Meta-Analysis

International Journal of COPD
Alice M Turner,1 Priscilla Wittkopf,2 Caroline von Wilamowitz-Moellendorff,2 Kyle Fahrbach,3 Mariana Farraia,4 May Hagiwara,5 Ed G Marins,5 Anne E Wyman,5 Lisi Wang,5 Suna Park5 1School of Health Sciences, University of Birmingham, Birmingham, UK ...
Turner AM, Wittkopf P, von Wilamowitz-Moellendorff C, Fahrbach K, Farraia M, Hagiwara M, Marins EG, Wyman AE, Wang L, Park S   +9 more
doaj  

Effectiveness and Safety of Nusinersen and Risdiplam in Spinal Muscular Atrophy: A Systematic Review

Annals of Clinical and Translational Neurology
Objective Spinal Muscular Atrophy (SMA) is a rare genetic disorder marked by progressive muscle weakness and mobility loss. It has a profound physical, emotional and social impact on patients and caregivers, requiring comprehensive medical and supportive
Amin Mehrabian, Peter Auguste, Amy Grove, Anna Brown, Janette Parr, Mubarak Patel, Furqan Butt, Jeremiah Donoghue, Mehdi Yousefi, Jo Parsons   +9 more
doaj   +1 more source