Results 161 to 170 of about 1,370,629 (264)

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Evaluating Large Language Models for Automated Evidence Synthesis in Neuroimaging AI: A Multi-Model Benchmark. [PDF]

J Clin Med
Sulaimanov U, Sanlier N, Moniri A, Demir B, Serikkanov Y, Bayramoglu AR, Al-Jebur MS, Sanlier MY, Erginoglu U, Otles E, Ammanuel SG, Keles A, Erginoglu U, Baskaya MK.   +13 more
europepmc   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

Evidence synthesis for sustainability [PDF]

Nature Sustainability, 2020
openaire   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Global burden of Wilson disease: a comprehensive evidence synthesis. [PDF]

Orphanet J Rare Dis
Tang S, Hou W, Yu H, Wang Y, Jiang H, Duan Z, Zheng S.   +6 more
europepmc   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Probiotics for treating acute diarrhea in children: an evidence synthesis. [PDF]

Front Pediatr
Chen C, Liu P, Xiao L, Cao Q, Zhou D, Liu X, Shen M, Jia X, Zhang L.   +8 more
europepmc   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Prevalence of Active HCV Infection in Spain in 2022 Using Multiparameter Evidence Synthesis. [PDF]

J Viral Hepat
Thomadakis C, Gountas I, Gountas K, Nuño N, Brime B, Sendino R, Albillos A, Buti M, Crespo J, Berenguer J, Alonso S, de Santiago AD, Hernando V, Laguno M, Lens S, Diago M, Montes ML, García-Samaniego J, Morano L, Moreno JL, Navarro J, Romero-Gómez M, Santos L, Soriano R, Duffell E, Diaz A, Del Amo J, Nikolopoulos G.   +27 more
europepmc   +1 more source