Results 91 to 100 of about 39,995 (281)
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Looking for evidentiality (and mirativity) in Bantu
Studies in African LinguisticsAlthough Bantu languages are not known for having grammaticalized and obligatory systems of evidentiality, research is uncovering more and more evidential contrasts and evidential strategies, as well as expressions of related categories like mirativity.
Thera Marie Crane
doaj
Studies in African Languages and CulturesExisting linguistic studies in Nigeria have focused on investigator’s communicative acts in coercive investigative discourse, with little attention given to non-coercive investigative discourse involving accused rapists (ARs) in correctional centres ...
Albert L. Oyeleye +2 more
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Evidential Reasoning Approach for Predicting Popularity of Instagram Posts
IEEE AccessMachine learning predictive models are increasingly used to analyse social media data. However, they often fall short in transparency and interpretability.
L. Rivadeneira, I. Loor
doaj +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
On Evidential Strategies in Manchu [PDF]
Saksaha: A Journal of Manchu Studies, 2016 Liliya M. Gorelova, Arthur Chen
openaire +1 more source
Probabilistic expert systems for handling artifacts in complex DNA mixtures [PDF]
, 2009 This paper presents a coherent probabilistic framework for taking account of allelic dropout, stutter bands and silent alleles when interpreting STR DNA profiles from a mixture sample using peak size information arising from a PCR analysis.
Cowell, R. +2 more
core +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source