Results 111 to 120 of about 4,062 (291)
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
The archivist in the electronic age [PDF]
, 2001 The article looks at the changing role of the archivist in the electronic age. It considers the new challenges posed, and some of the ways in which they are being met. Physical threats to records include technology obsolescence and physical deterioration
Hollier, Anita, Hollier, A
core
The Syntax of Speech Acts: Deictic Inversion as an Evidential Strategy in English
LanguagesThis paper presents empirical evidence to support the so-called syntactization of discourse, that is, the projection of relevant pragmatic features in the narrow syntax. In particular, it analyses deictic inversion in English, a construction which is used by the speaker to point at a proximal or distal location and bring the addressee’s attention to an
openaire +3 more sources
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Evidential Map-Building Approaches for Multi-UAV
, 2005 — This paper addresses the map building problem for cooperative search by a team of Uninhabited Air Vehicles (UAVs) operating in an unknown and uncertain environment.
Yanli Yang Ali A. Minai
core
E-NER: Evidential Deep Learning for Trustworthy Named Entity Recognition
, 2023 Most named entity recognition (NER) systems focus on improving model performance, ignoring the need to quantify model uncertainty, which is critical to the reliability of NER systems in open environments.
Hu, Mengting +8 more
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